Ranbp1 RAN binding protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ranbp1provided by RGD
Official Full Name: RAN binding protein 1provided by RGD
Primary source: RGD:1310521
See related: EnsemblRapid:ENSRNOG00000001884 AllianceGenome:RGD:1310521
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable GDP-dissociation inhibitor activity. Predicted to contribute to GTPase activator activity. Involved in several processes, including cellular response to leptomycin B; positive regulation of neuron projection development; and response to calcium ion. Located in axon cytoplasm. Biomarker of myocardial infarction and sciatic neuropathy. Orthologous to human RANBP1 (RAN binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 351.8), Kidney (RPKM 221.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q23

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (96246912..96255145)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (82742603..82750836)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (86890585..86898818)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ranbp1 (e-PCR), detects polymorphism
- UniSTS:265741

EST9C6 (e-PCR)
- UniSTS:263442

UniSTS:237455 (e-PCR)
- UniSTS:237455

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GDP-dissociation inhibitor activity	ISO Inferred from Sequence Orthology more info
contributes_to GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to leptomycin B	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in nucleocytoplasmic transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mitotic centrosome separation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of mitotic centrosome separation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to calcium ion	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within spindle organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane bounded cell projection cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ran-specific GTPase-activating protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.