Piezo1 piezo-type mechanosensitive ion channel component 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Piezo1provided by RGD
Official Full Name: piezo-type mechanosensitive ion channel component 1provided by RGD
Primary source: RGD:1308822
See related: EnsemblRapid:ENSRNOG00000056786 AllianceGenome:RGD:1308822
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mib; Fam38a
Summary: Predicted to enable identical protein binding activity and mechanosensitive monoatomic cation channel activity. Predicted to be involved in several processes, including cellular response to mechanical stimulus; positive regulation of cell-cell adhesion mediated by integrin; and positive regulation of myotube differentiation. Predicted to act upstream of or within monoatomic cation transmembrane transport. Predicted to be located in cuticular plate and stereocilium. Predicted to be active in endoplasmic reticulum and plasma membrane. Human ortholog(s) of this gene implicated in dehydrated hereditary stomatocytosis 1 and hereditary lymphedema. Orthologous to human PIEZO1 (piezo type mechanosensitive ion channel component 1 (Er blood group)). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 81.4), Spleen (RPKM 64.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 53

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (67453120..67515347, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (50544580..50606812, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (55305494..55367680, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mechanosensitive Piezo1 channels promote neurogenic bladder fibrosis via regulating TGF-beta1/smad and Hippo/YAP1 pathways.
Title: Mechanosensitive Piezo1 channels promote neurogenic bladder fibrosis via regulating TGF-β1/smad and Hippo/YAP1 pathways.
Biomechanism of abnormal stress on promoting osteoarthritis of temporomandibular joint through Piezo1 ion channel.
Title: Biomechanism of abnormal stress on promoting osteoarthritis of temporomandibular joint through Piezo1 ion channel.
Activation of Piezo1 by intracranial hypertension induced neuronal apoptosis via activating hippo pathway.
Title: Activation of Piezo1 by intracranial hypertension induced neuronal apoptosis via activating hippo pathway.
Piezo1 mediates the degradation of cartilage extracellular matrix in malocclusion-induced TMJOA.
Title: Piezo1 mediates the degradation of cartilage extracellular matrix in malocclusion-induced TMJOA.
Piezo1-Mediated Neurogenic Inflammatory Cascade Exacerbates Ventricular Remodeling After Myocardial Infarction.
Title: Piezo1-Mediated Neurogenic Inflammatory Cascade Exacerbates Ventricular Remodeling After Myocardial Infarction.
Long-term simulated microgravity fosters carotid aging-like changes via Piezo1.
Title: Long-term simulated microgravity fosters carotid aging-like changes via Piezo1.
Inhibition of piezo1 prevents chronic cerebral hypoperfusion-induced cognitive impairment and blood brain barrier disruption.
Title: Inhibition of piezo1 prevents chronic cerebral hypoperfusion-induced cognitive impairment and blood brain barrier disruption.
Cell-cell and cell-matrix adhesion regulated by Piezo1 is critical for stiffness-dependent DRG neuron aggregation.
Title: Cell-cell and cell-matrix adhesion regulated by Piezo1 is critical for stiffness-dependent DRG neuron aggregation.
Role of mechanosensitive ion channel Piezo1 in tension-side orthodontic alveolar bone remodeling in rats.
Title: Role of mechanosensitive ion channel Piezo1 in tension-side orthodontic alveolar bone remodeling in rats.
A regulatory role of Piezo1 in apoptosis of periodontal tissue and periodontal ligament fibroblasts during orthodontic tooth movement.
Title: A regulatory role of Piezo1 in apoptosis of periodontal tissue and periodontal ligament fibroblasts during orthodontic tooth movement.

Submit: New GeneRIF Correction See all GeneRIFs (31)

General gene information

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Markers

MARC_12079-12080:1004624307:1 (e-PCR)
- UniSTS:267331

MARC_12079-12080:1007732326:1 (e-PCR)
- UniSTS:267331

RH131577 (e-PCR)
- UniSTS:214860

RH141716 (e-PCR)
- UniSTS:223709

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables mechanosensitive monoatomic cation channel activity	IEA Inferred from Electronic Annotation more info
enables mechanosensitive monoatomic cation channel activity	ISO Inferred from Sequence Orthology more info
enables mechanosensitive monoatomic ion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables mechanosensitive monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables mechanosensitive monoatomic ion channel activity	ISO Inferred from Sequence Orthology more info
enables mechanosensitive monoatomic ion channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables monoatomic cation channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables monoatomic cation channel activity	ISO Inferred from Sequence Orthology more info
enables monoatomic cation channel activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cellular response to mechanical stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in detection of mechanical stimulus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within detection of mechanical stimulus	ISO Inferred from Sequence Orthology more info
involved_in monoatomic cation transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic cation transport	ISO Inferred from Sequence Orthology more info
involved_in monoatomic cation transport	ISO Inferred from Sequence Orthology more info
involved_in monoatomic cation transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell-cell adhesion mediated by integrin	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell-cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell-cell adhesion mediated by integrin	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of integrin activation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of integrin activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of integrin activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of myotube differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of myotube differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myotube differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of membrane potential	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of membrane potential	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cuticular plate	ISO Inferred from Sequence Orthology more info
located_in cuticular plate	ISS Inferred from Sequence or Structural Similarity more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum-Golgi intermediate compartment membrane	IEA Inferred from Electronic Annotation more info
located_in lamellipodium membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in stereocilium	ISO Inferred from Sequence Orthology more info
located_in stereocilium	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: piezo-type mechanosensitive ion channel component 1

Names: family with sequence similarity 38, member A; membrane protein induced by beta-amyloid treatment; protein PIEZO1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001434583.1 → NP_001421512.1 piezo-type mechanosensitive ion channel component 1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/Swiss-Prot

Q0KL00

UniProtKB/TrEMBL

A0A0G2JWS3
NM_001434584.1 → NP_001421513.1 piezo-type mechanosensitive ion channel component 1 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/Swiss-Prot

Q0KL00

UniProtKB/TrEMBL

A0A8I5Y135

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

67453120..67515347 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008772627.4 → XP_008770849.1 piezo-type mechanosensitive ion channel component 1 isoform X2

Related

ENSRNOP00000077382.1, ENSRNOT00000105150.2

Conserved Domains (2) summary

pfam12166
Location:2093 → 2511

Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain

pfam15917
Location:1223 → 1421

PIEZO; Piezo
XM_008772626.4 → XP_008770848.1 piezo-type mechanosensitive ion channel component 1 isoform X1

Related

ENSRNOP00000069995.2, ENSRNOT00000091139.3

Conserved Domains (2) summary

pfam12166
Location:2117 → 2535

Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain

pfam15917
Location:1223 → 1445

PIEZO; Piezo
XM_039097875.2 → XP_038953803.1 piezo-type mechanosensitive ion channel component 1 isoform X3

UniProtKB/Swiss-Prot

Q0KL00

Conserved Domains (2) summary

pfam12166
Location:2034 → 2452

Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain

pfam15917
Location:1140 → 1365

PIEZO; Piezo
XM_017601325.3 → XP_017456814.1 piezo-type mechanosensitive ion channel component 1 isoform X3

UniProtKB/Swiss-Prot

Q0KL00

Conserved Domains (2) summary

pfam12166
Location:2034 → 2452

Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain

pfam15917
Location:1140 → 1365

PIEZO; Piezo
XM_063278152.1 → XP_063134222.1 piezo-type mechanosensitive ion channel component 1 isoform X4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001077200.2: Suppressed sequence

Description

NM_001077200.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.