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    Mdga1 MAM domain containing glycosylphosphatidylinositol anchor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309659, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mdga1provided by RGD
    Official Full Name
    MAM domain containing glycosylphosphatidylinositol anchor 1provided by RGD
    Primary source
    RGD:1307031
    See related
    EnsemblRapid:ENSRNOG00000000536 AllianceGenome:RGD:1307031
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Involved in central nervous system development and regulation of synapse organization. Located in plasma membrane. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic density membrane. Orthologous to human MDGA1 (MAM domain containing glycosylphosphatidylinositol anchor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 21.3), Brain (RPKM 12.2) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mdga1 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (7901856..7965834, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (7900327..7964309, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (8515142..8574632, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S20 like 5 Neighboring gene ribosomal protein S15, pseudogene 19 Neighboring gene uncharacterized LOC120098975 Neighboring gene uncharacterized LOC120098917 Neighboring gene uncharacterized LOC120098952

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MDGAs are fast-diffusing molecules that delay excitatory synapse development by altering neuroligin behavior. Toledo A, et al. Elife, 2022 May 9. PMID 35532105, Free PMC Article
    2. Radial migration of superficial layer cortical neurons controlled by novel Ig cell adhesion molecule MDGA1. Takeuchi A, et al. J Neurosci, 2006 Apr 26. PMID 16641224, Free PMC Article
    3. Characterization of MDGA1, a novel human glycosylphosphatidylinositol-anchored protein localized in lipid rafts. Díaz-López A, et al. Exp Cell Res, 2005 Jul 1. PMID 15922729
    4. Upregulation of Spinal MDGA1 in Rats After Nerve Injury Alters Interactions Between Neuroligin-2 and Postsynaptic Scaffolding Proteins and Increases GluR1 Subunit Surface Delivery in the Spinal Cord Dorsal Horn. Li HL, et al. Neurochem Res, 2024 Feb. PMID 37955815
    5. Molecular Mechanism of MDGA1: Regulation of Neuroligin 2:Neurexin Trans-synaptic Bridges. Gangwar SP, et al. Neuron, 2017 Jun 21. PMID 28641112, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Upregulation of Spinal MDGA1 in Rats After Nerve Injury Alters Interactions Between Neuroligin-2 and Postsynaptic Scaffolding Proteins and Increases GluR1 Subunit Surface Delivery in the Spinal Cord Dorsal Horn.
      Title: Upregulation of Spinal MDGA1 in Rats After Nerve Injury Alters Interactions Between Neuroligin-2 and Postsynaptic Scaffolding Proteins and Increases GluR1 Subunit Surface Delivery in the Spinal Cord Dorsal Horn.
    2. MDGA binding and suppression of synaptogenic activity was selective for neuroligin-2 and not neuroligin-1 excitatory synapse organizer.
      Title: Interaction between autism-linked MDGAs and neuroligins suppresses inhibitory synapse development.
    3. MDGAs interact selectively with neuroligin-2 but not other neuroligins to regulate inhibitory synapse development.
      Title: MDGAs interact selectively with neuroligin-2 but not other neuroligins to regulate inhibitory synapse development.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in brain development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cerebral cortex radially oriented cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cerebral cortex radially oriented cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in inhibitory synapse assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within inhibitory synapse assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of synapse assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within neuron migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in presynapse assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within presynapse assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of presynapse assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of presynapse assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of synapse maturation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of synapse maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of synaptic membrane adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of synaptic membrane adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spinal cord association neuron differentiation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in GABA-ergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in GABA-ergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in GABA-ergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic density membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    MAM domain-containing glycosylphosphatidylinositol anchor protein 1
    Names
    ig6M

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001414944.1 → NP_001401873.1  MAM domain-containing glycosylphosphatidylinositol anchor protein 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/Swiss-Prot
      P85171
      UniProtKB/TrEMBL
      A0A140TAF4
      Related
      ENSRNOP00000111019.1, ENSRNOT00000124884.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      7901856..7965834 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017601653.3 → XP_017457142.1  MAM domain-containing glycosylphosphatidylinositol anchor protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A140TAF4
      Related
      ENSRNOP00000099314.1, ENSRNOT00000140475.1

    2. XM_039098719.2 → XP_038954647.1  MAM domain-containing glycosylphosphatidylinositol anchor protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A140TAF4
      Related
      ENSRNOP00000040424.7, ENSRNOT00000048845.7
      Conserved Domains (6) summary
      smart00408
      Location:254 → 315
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:450 → 535
      IG_like; Immunoglobulin like
      pfam00629
      Location:754 → 890
      MAM; MAM domain, meprin/A5/mu
      pfam13927
      Location:132 → 217
      Ig_3; Immunoglobulin domain
      cd00096
      Location:240 → 242
      Ig; Ig strand A [structural motif]
      cl11960
      Location:54 → 115
      Ig; Immunoglobulin domain

    3. XM_039098720.2 → XP_038954648.1  MAM domain-containing glycosylphosphatidylinositol anchor protein 1 isoform X3

      Conserved Domains (5) summary
      smart00408
      Location:254 → 315
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:450 → 535
      IG_like; Immunoglobulin like
      pfam13927
      Location:132 → 217
      Ig_3; Immunoglobulin domain
      cd00096
      Location:240 → 242
      Ig; Ig strand A [structural motif]
      cl11960
      Location:54 → 115
      Ig; Immunoglobulin domain

    4. XM_039098721.2 → XP_038954649.1  MAM domain-containing glycosylphosphatidylinositol anchor protein 1 isoform X4

      Conserved Domains (5) summary
      smart00408
      Location:254 → 315
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:450 → 535
      IG_like; Immunoglobulin like
      pfam13927
      Location:132 → 217
      Ig_3; Immunoglobulin domain
      cd00096
      Location:240 → 242
      Ig; Ig strand A [structural motif]
      cl11960
      Location:54 → 115
      Ig; Immunoglobulin domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107618.1: Suppressed sequence

      Description
      NM_001107618.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P85171.1 GenPept UniProtKB/Swiss-Prot:P85171

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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