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    Adck2 aarF domain containing kinase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312258, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adck2provided by RGD
    Official Full Name
    aarF domain containing kinase 2provided by RGD
    Primary source
    RGD:1311058
    See related
    EnsemblRapid:ENSRNOG00000010005 AllianceGenome:RGD:1311058
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in regulation of ubiquinone biosynthetic process. Predicted to be active in mitochondrion. Orthologous to human ADCK2 (aarF domain containing kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 55.3), Thymus (RPKM 46.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Adck2 in Genome Data Viewer
    Location:
    4q23
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (69315633..69328535)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (68348853..68362725)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (67359531..67373390)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene DENN domain containing 2A Neighboring gene serine and arginine rich splicing factor 3, pseudogene 6 Neighboring gene thymosin, beta 10, pseudogene 5 Neighboring gene NADH:ubiquinone oxidoreductase subunit B2 Neighboring gene B-Raf proto-oncogene, serine/threonine kinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in regulation of ubiquinone biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized aarF domain-containing protein kinase 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107855.1 → NP_001101325.1  uncharacterized aarF domain-containing protein kinase 2

      See identical proteins and their annotated locations for NP_001101325.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473959
      UniProtKB/TrEMBL
      A0A8I6GIH2, A6IEV4, D3ZRE6
      Related
      ENSRNOP00000013277.5, ENSRNOT00000013277.8
      Conserved Domains (2) summary
      COG0661
      Location:133 → 610
      AarF; Predicted unusual protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme transport and metabolism, Signal transduction mechanisms]
      cd13971
      Location:168 → 543
      ADCK2-like; aarF domain containing kinase 2 and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      69315633..69328535
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008762782.4 → XP_008761004.1  uncharacterized aarF domain-containing protein kinase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GIH2
      Conserved Domains (2) summary
      COG0661
      Location:133 → 518
      AarF; Predicted unusual protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme transport and metabolism, Signal transduction mechanisms]
      cd13971
      Location:168 → 543
      ADCK2-like; aarF domain containing kinase 2 and similar proteins

    2. XM_006236325.5 → XP_006236387.1  uncharacterized aarF domain-containing protein kinase 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GIH2
      Conserved Domains (2) summary
      COG0661
      Location:133 → 469
      AarF; Predicted unusual protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme transport and metabolism, Signal transduction mechanisms]
      cd13971
      Location:168 → 494
      ADCK2-like; aarF domain containing kinase 2 and similar proteins

    3. XM_006236326.5 → XP_006236388.1  uncharacterized aarF domain-containing protein kinase 2 isoform X3

      See identical proteins and their annotated locations for XP_006236388.1

      UniProtKB/TrEMBL
      A0A8I6GIH2, B1WBW8
      Related
      ENSRNOP00000074988.1, ENSRNOT00000082241.3
      Conserved Domains (2) summary
      COG0661
      Location:133 → 561
      AarF; Predicted unusual protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme transport and metabolism, Signal transduction mechanisms]
      cd13971
      Location:168 → 494
      ADCK2-like; aarF domain containing kinase 2 and similar proteins

    4. XM_039107527.2 → XP_038963455.1  uncharacterized aarF domain-containing protein kinase 2 isoform X5

      Conserved Domains (1) summary
      cl21453
      Location:168 → 429
      PKc_like; Protein Kinases, catalytic domain

    5. XM_039107526.2 → XP_038963454.1  uncharacterized aarF domain-containing protein kinase 2 isoform X4

      Conserved Domains (1) summary
      cl21453
      Location:168 → 427
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version

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