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    Galc galactosylceramidase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314360, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Galcprovided by RGD
    Official Full Name
    galactosylceramidaseprovided by RGD
    Primary source
    RGD:1359384
    See related
    EnsemblRapid:ENSRNOG00000003759 AllianceGenome:RGD:1359384
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable galactosylceramidase activity. Predicted to be involved in galactosylceramide catabolic process. Predicted to act upstream of or within myelination. Predicted to be active in lysosome. Human ortholog(s) of this gene implicated in Krabbe disease. Orthologous to human GALC (galactosylceramidase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 273.8), Kidney (RPKM 115.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Galc in Genome Data Viewer
    Location:
    6q32
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (123182636..123252024, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (117452888..117522281, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (122177195..122239411, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene cofilin 1, pseudogene 1 Neighboring gene uncharacterized LOC120093266 Neighboring gene G-protein coupled receptor 65 Neighboring gene uncharacterized LOC120103597 Neighboring gene potassium two pore domain channel subfamily K member 10 Neighboring gene U7 small nuclear RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Antibodies to Protein but Not Glycolipid Structures Are Important for Host Defense against Mycoplasma pneumoniae. Meyer Sauteur PM, et al. Infect Immun, 2019 Feb. PMID 30396892, Free PMC Article
    2. Altered gene transcription linked to astrocytes and oligodendrocytes in frontal cortex in Creutzfeldt-Jakob disease. Andres Benito P, et al. Prion, 2018. PMID 30009661, Free PMC Article
    3. Intrathecal antibody responses to GalC in Guillain-Barré syndrome triggered by Mycoplasma pneumoniae. Meyer Sauteur PM, et al. J Neuroimmunol, 2018 Jan 15. PMID 29301655
    4. Mycoplasma pneumoniae triggering the Guillain-Barré syndrome: A case-control study. Meyer Sauteur PM, et al. Ann Neurol, 2016 Oct. PMID 27490360
    5. Cross-reactive anti-galactocerebroside antibodies and Mycoplasma pneumoniae infections in Guillain-Barré syndrome. Ang CW, et al. J Neuroimmunol, 2002 Sep. PMID 12225900

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables galactosylceramidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables galactosylceramidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in galactosylceramide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within galactosylceramide catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in galactosylceramide catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within myelination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    galactocerebrosidase
    NP_001005888.1
    XP_017449653.1
    XP_038968259.1
    XP_063118026.1
    XP_063118027.1
    XP_063118028.1
    XP_063118029.1
    XP_063118030.1
    XP_063118031.1
    XP_063118032.1
    XP_063118033.1
    XP_063118034.1
    XP_063118035.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005888.1 → NP_001005888.1  galactocerebrosidase precursor

      See identical proteins and their annotated locations for NP_001005888.1

      Status: PROVISIONAL

      Source sequence(s)
      AY386370
      UniProtKB/TrEMBL
      A0A0G2QC23, A6JEE0, G3V6H1, Q5YKG1
      Conserved Domains (2) summary
      pfam02057
      Location:1 → 668
      Glyco_hydro_59; Glycosyl hydrolase family 59
      cl23815
      Location:16 → 297
      Glyco_hydro_30; O-Glycosyl hydrolase family 30

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      123182636..123252024 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063261959.1 → XP_063118029.1  galactocerebrosidase isoform X3

      UniProtKB/TrEMBL
      A6JEE0, G3V6H1, Q5YKG1

    2. XM_039112331.1 → XP_038968259.1  galactocerebrosidase isoform X4

      UniProtKB/TrEMBL
      A6JEE0, G3V6H1, Q5YKG1
      Conserved Domains (2) summary
      pfam02057
      Location:1 → 233
      Glyco_hydro_59; Glycosyl hydrolase family 59
      pfam17387
      Location:241 → 357
      Glyco_hydro_59M; Glycosyl hydrolase family 59 central domain

    3. XM_063261963.1 → XP_063118033.1  galactocerebrosidase isoform X3

      UniProtKB/TrEMBL
      A6JEE0, G3V6H1, Q5YKG1

    4. XM_063261956.1 → XP_063118026.1  galactocerebrosidase isoform X1

      UniProtKB/TrEMBL
      A6JEE0, G3V6H1, Q5YKG1
      Related
      ENSRNOP00000005015.7, ENSRNOT00000005015.8

    5. XM_063261964.1 → XP_063118034.1  galactocerebrosidase isoform X3

      UniProtKB/TrEMBL
      A6JEE0, G3V6H1, Q5YKG1

    6. XM_017594164.3 → XP_017449653.1  galactocerebrosidase isoform X4

      UniProtKB/TrEMBL
      A6JEE0, G3V6H1, Q5YKG1
      Conserved Domains (2) summary
      pfam02057
      Location:1 → 233
      Glyco_hydro_59; Glycosyl hydrolase family 59
      pfam17387
      Location:241 → 357
      Glyco_hydro_59M; Glycosyl hydrolase family 59 central domain

    7. XM_063261958.1 → XP_063118028.1  galactocerebrosidase isoform X3

      UniProtKB/TrEMBL
      A6JEE0, G3V6H1, Q5YKG1

    8. XM_063261961.1 → XP_063118031.1  galactocerebrosidase isoform X3

      UniProtKB/TrEMBL
      A6JEE0, G3V6H1, Q5YKG1

    9. XM_063261960.1 → XP_063118030.1  galactocerebrosidase isoform X3

      UniProtKB/TrEMBL
      A6JEE0, G3V6H1, Q5YKG1

    10. XM_063261962.1 → XP_063118032.1  galactocerebrosidase isoform X3

      UniProtKB/TrEMBL
      A6JEE0, G3V6H1, Q5YKG1

    11. XM_063261957.1 → XP_063118027.1  galactocerebrosidase isoform X2

      UniProtKB/TrEMBL
      A6JEE0, G3V6H1, Q5YKG1
      Related
      ENSRNOP00000102789.1, ENSRNOT00000138952.1

    12. XM_063261965.1 → XP_063118035.1  galactocerebrosidase isoform X3

      UniProtKB/TrEMBL
      A6JEE0, G3V6H1, Q5YKG1

    RNA

    1. XR_010052097.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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