Abo3 histo-blood group ABO system transferase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Abo3provided by RGD
Official Full Name: histo-blood group ABO system transferase 3provided by RGD
Primary source: RGD:628609
See related: EnsemblRapid:ENSRNOG00000039906 AllianceGenome:RGD:628609
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Abo; Abol1
Summary: Enables glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity. Involved in defense response to bacterium. Predicted to be located in Golgi cisterna membrane and extracellular region. Predicted to be active in Golgi apparatus and vesicle. Human ortholog(s) of this gene implicated in several diseases, including Plasmodium falciparum malaria; graft-versus-host disease; leukemia (multiple); lung disease (multiple); and severe acute respiratory syndrome. Orthologous to human ABO (ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 4.9), Heart (RPKM 3.3) and 9 other tissues See more
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Genomic context

Location:: 3p13

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (30141941..30159129)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (9743861..9761049)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (5109880..5127376)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

data indicate that rats have at least two distinct Abo genes, one monomorphic gene encoding a B-specific enzyme and one or more genes in some cases encoding an A-specific enzyme
Title: Cloning of a rat gene encoding the histo-blood group B enzyme: rats have more than one Abo gene.
The complete coding sequence of a BDIX rat gene homologous to the human ABO gene was determined. It had strong UDP-GalNAc:Fucalpha1,2GalalphaGalNAc transferase activity and a small UDP-Gal:Fucalpha1,2GalalphaGal transferase activity.
Title: Cloning of a rat gene encoding the histo-blood group A enzyme. Tissue expression of the gene and of the A and B antigens.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables fucosylgalactoside 3-alpha-galactosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glycosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hexosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in defense response to bacterium	IEP Inferred from Expression Pattern more info	PubMed
involved_in lipid glycosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi cisterna membrane	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in vesicle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: histo-blood group ABO system transferase 1

Names: ABO blood group (alpha 1-3-N-acetylgalactosaminyltransferase, alpha 1-3-galactosyltransferase); ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase); ABO blood group (transferase B, alpha 1-3-galactosyltransferase); ABO blood group-like 1; B blood group galactosyltransferase; N-acetylgalactosaminyltransferase A blood group-like enzyme; NAGAT 1; a transferase; alpha 1-3-N-acetylgalactosaminyltransferase-like 1; b transferase; blood group A glycosyltransferase 1; cis-AB transferase 1; fucosylglycoprotein 3-alpha-galactosyltransferase; fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase; globoside alpha-1,3-N-acetylgalactosaminyltransferase 1; glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase; glycoprotein-fucosylgalactoside alpha-galactosyltransferase; histo-blood group A transferase; histo-blood group B transferase; transferase B, alpha 1-3-galactosyltransferase)

NP_075582.3

EC 2.4.1.37

EC 2.4.1.40

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.