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    Ascc3 activating signal cointegrator 1 complex subunit 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309887, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ascc3provided by RGD
    Official Full Name
    activating signal cointegrator 1 complex subunit 3provided by RGD
    Primary source
    RGD:1307995
    See related
    AllianceGenome:RGD:1307995
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Helic1
    Summary
    Predicted to enable 3'-5' DNA helicase activity and ATP hydrolysis activity. Predicted to be involved in several processes, including DNA alkylation repair; rescue of stalled ribosome; and ribosome-associated ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol. Predicted to be part of DNA repair complex and activating signal cointegrator 1 complex. Predicted to be active in cytosolic ribosome and nucleus. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder. Orthologous to human ASCC3 (activating signal cointegrator 1 complex subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 176.9), Adrenal (RPKM 155.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ascc3 in Genome Data Viewer
    Location:
    20q13
    Exon count:
    47
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (55089430..55372374)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (53510137..53795446)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (55253670..55557249)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene elongation factor 1-alpha 1-like Neighboring gene sperm motility kinase like, pseudogene 8 Neighboring gene uncharacterized LOC134483837 Neighboring gene SIM bHLH transcription factor 1 Neighboring gene lysophospholipase 1, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation. Dango S, et al. Mol Cell, 2011 Nov 4. PMID 22055184, Free PMC Article
    2. Novel transcription coactivator complex containing activating signal cointegrator 1. Jung DJ, et al. Mol Cell Biol, 2002 Jul. PMID 12077347, Free PMC Article
    3. FMRP recruitment of β-catenin to the translation pre-initiation complex represses translation. Ehyai S, et al. EMBO Rep, 2018 Dec. PMID 30361391, Free PMC Article
    4. p38α MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes. Dumont AA, et al. Biochim Biophys Acta Mol Cell Res, 2019 Dec. PMID 31505169
    5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC189522

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3'-5' DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3'-5' DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 3'-5' DNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP hydrolysis activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables forked DNA-dependent helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables four-way junction helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded 3'-5' DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA alkylation repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA alkylation repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in DNA duplex unwinding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA duplex unwinding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rescue of stalled ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rescue of stalled ribosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ribosome disassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosome disassembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ribosome-associated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosome-associated ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of DNA repair complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of activating signal cointegrator 1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    activating signal cointegrator 1 complex subunit 3
    Names
    helicase, ATP binding 1
    NP_001263986.1
    XP_006256664.1
    XP_006256665.1
    XP_008771214.1
    XP_008771215.1
    XP_038954701.1
    XP_063135250.1
    XP_063135251.1
    XP_063135253.1
    XP_063135254.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277057.1 → NP_001263986.1  activating signal cointegrator 1 complex subunit 3

      See identical proteins and their annotated locations for NP_001263986.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      A0A0A0MY43, A6K6T5
      Conserved Domains (2) summary
      COG1204
      Location:478 → 1240
      BRR2; Replicative superfamily II helicase [Replication, recombination and repair]
      cd18022
      Location:1327 → 1515
      DEXHc_ASCC3_2; C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      55089430..55372374
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279181.1 → XP_063135251.1  activating signal cointegrator 1 complex subunit 3 isoform X1

      UniProtKB/TrEMBL
      A0A0A0MY43, A6K6T5

    2. XM_063279180.1 → XP_063135250.1  activating signal cointegrator 1 complex subunit 3 isoform X1

      UniProtKB/TrEMBL
      A0A0A0MY43, A6K6T5

    3. XM_006256602.5 → XP_006256664.1  activating signal cointegrator 1 complex subunit 3 isoform X1

      See identical proteins and their annotated locations for XP_006256664.1

      UniProtKB/TrEMBL
      A0A0A0MY43, A6K6T5
      Conserved Domains (2) summary
      COG1204
      Location:478 → 1240
      BRR2; Replicative superfamily II helicase [Replication, recombination and repair]
      cd18022
      Location:1327 → 1515
      DEXHc_ASCC3_2; C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3

    4. XM_063279184.1 → XP_063135254.1  activating signal cointegrator 1 complex subunit 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZWJ5, A6K6T5

    5. XM_008772992.4 → XP_008771214.1  activating signal cointegrator 1 complex subunit 3 isoform X1

      See identical proteins and their annotated locations for XP_008771214.1

      UniProtKB/TrEMBL
      A0A0A0MY43, A6K6T5
      Conserved Domains (2) summary
      COG1204
      Location:478 → 1240
      BRR2; Replicative superfamily II helicase [Replication, recombination and repair]
      cd18022
      Location:1327 → 1515
      DEXHc_ASCC3_2; C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3

    6. XM_006256603.5 → XP_006256665.1  activating signal cointegrator 1 complex subunit 3 isoform X1

      See identical proteins and their annotated locations for XP_006256665.1

      UniProtKB/TrEMBL
      A0A0A0MY43, A6K6T5
      Conserved Domains (2) summary
      COG1204
      Location:478 → 1240
      BRR2; Replicative superfamily II helicase [Replication, recombination and repair]
      cd18022
      Location:1327 → 1515
      DEXHc_ASCC3_2; C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3

    7. XM_039098773.2 → XP_038954701.1  activating signal cointegrator 1 complex subunit 3 isoform X1

      UniProtKB/TrEMBL
      A0A0A0MY43, A6K6T5
      Conserved Domains (2) summary
      COG1204
      Location:478 → 1240
      BRR2; Replicative superfamily II helicase [Replication, recombination and repair]
      cd18022
      Location:1327 → 1515
      DEXHc_ASCC3_2; C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3

    8. XM_063279183.1 → XP_063135253.1  activating signal cointegrator 1 complex subunit 3 isoform X1

      UniProtKB/TrEMBL
      A0A0A0MY43, A6K6T5

    9. XM_008772993.4 → XP_008771215.1  activating signal cointegrator 1 complex subunit 3 isoform X1

      See identical proteins and their annotated locations for XP_008771215.1

      UniProtKB/TrEMBL
      A0A0A0MY43, A6K6T5
      Conserved Domains (2) summary
      COG1204
      Location:478 → 1240
      BRR2; Replicative superfamily II helicase [Replication, recombination and repair]
      cd18022
      Location:1327 → 1515
      DEXHc_ASCC3_2; C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3

    RNA

    1. XR_010060704.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107640.1: Suppressed sequence

      Description
      NM_001107640.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F1LPQ2.1 GenPept UniProtKB/Swiss-Prot:F1LPQ2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials