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    Dennd2a DENN domain containing 2A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312257, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dennd2aprovided by RGD
    Official Full Name
    DENN domain containing 2Aprovided by RGD
    Primary source
    RGD:1306142
    See related
    EnsemblRapid:ENSRNOG00000026748 AllianceGenome:RGD:1306142
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306142
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in retrograde transport, endosome to Golgi. Predicted to be located in cytosol. Predicted to be active in actin cytoskeleton. Orthologous to human DENND2A (DENN domain containing 2A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 63.7), Liver (RPKM 42.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dennd2a in Genome Data Viewer
    Location:
    4q23
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (69199814..69299128, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (68233016..68332235, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (67242257..67342993, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene RAB19, member RAS oncogene family Neighboring gene makorin ring finger protein 1 Neighboring gene small nucleolar RNA SNORA71 Neighboring gene serine and arginine rich splicing factor 3, pseudogene 6 Neighboring gene aarF domain containing kinase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. Yoshimura S, et al. J Cell Biol, 2010 Oct 18. PMID 20937701, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DENN domain-containing protein 2A
    Names
    DENN/MADD domain containing 2A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427610.1 → NP_001414539.1  DENN domain-containing protein 2A

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I6AL22, D3ZLQ1
      Related
      ENSRNOP00000034734.3, ENSRNOT00000034549.7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      69199814..69299128 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063286009.1 → XP_063142079.1  DENN domain-containing protein 2A isoform X2

      UniProtKB/TrEMBL
      A0A8I6AL22

    2. XM_006236354.4 → XP_006236416.1  DENN domain-containing protein 2A isoform X1

      See identical proteins and their annotated locations for XP_006236416.1

      UniProtKB/TrEMBL
      A0A8I6AL22, D3ZLQ1
      Conserved Domains (3) summary
      smart00801
      Location:893 → 951
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:552 → 644
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:651 → 807
      DENN; DENN (AEX-3) domain

    3. XM_039109022.2 → XP_038964950.1  DENN domain-containing protein 2A isoform X2

      UniProtKB/TrEMBL
      A0A8I6AL22
      Conserved Domains (3) summary
      smart00801
      Location:892 → 950
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:551 → 643
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:650 → 806
      DENN; DENN (AEX-3) domain

    4. XM_039109021.2 → XP_038964949.1  DENN domain-containing protein 2A isoform X1

      UniProtKB/TrEMBL
      A0A8I6AL22, D3ZLQ1
      Conserved Domains (3) summary
      smart00801
      Location:893 → 951
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:552 → 644
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:651 → 807
      DENN; DENN (AEX-3) domain

    5. XM_008762851.3 → XP_008761073.1  DENN domain-containing protein 2A isoform X1

      See identical proteins and their annotated locations for XP_008761073.1

      UniProtKB/TrEMBL
      A0A8I6AL22, D3ZLQ1
      Conserved Domains (3) summary
      smart00801
      Location:893 → 951
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:552 → 644
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:651 → 807
      DENN; DENN (AEX-3) domain

    6. XM_063286008.1 → XP_063142078.1  DENN domain-containing protein 2A isoform X1

      UniProtKB/TrEMBL
      A0A8I6AL22, D3ZLQ1
    Nucleotide Protein Strain
    Heading Accession and Version

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