Rc3h2 ring finger and CCCH-type domains 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rc3h2provided by RGD
Official Full Name: ring finger and CCCH-type domains 2provided by RGD
Primary source: RGD:1304833
See related: EnsemblRapid:ENSRNOG00000009196 AllianceGenome:RGD:1304833
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mnab
Summary: Predicted to enable nucleic acid binding activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including T cell receptor signaling pathway; negative regulation of T-helper 17 cell differentiation; and regulation of RNA metabolic process. Predicted to act upstream of or within several processes, including T cell activation; hematopoietic or lymphoid organ development; and lymphocyte homeostasis. Predicted to be located in cell surface; intracellular membrane-bounded organelle; and membrane. Predicted to be active in cytoplasmic stress granule. Orthologous to human RC3H2 (ring finger and CCCH-type domains 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 250.5), Brain (RPKM 221.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q11

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (41531319..41596496, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (21121531..21186711, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (21621976..21676789, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

D3Got13 (e-PCR)
- UniSTS:111663

BE108864 (e-PCR)
- UniSTS:247906

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA stem-loop binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA stem-loop binding	ISO Inferred from Sequence Orthology more info
enables double-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded RNA binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within B cell homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within T cell homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within T follicular helper cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within limb development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung alveolus development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lymph node development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T-helper 17 cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within post-embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within post-transcriptional regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein polyubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of miRNA metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spleen development	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in P-body	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasmic stress granule	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: roquin-2

Names: RING finger and CCCH-type zinc finger domain-containing protein 2; membrane associated DNA binding protein; ring finger and CCCH-type zinc finger domains 2

NP_001101309.1

EC 2.3.2.27

XP_008759976.1

EC 2.3.2.27

XP_038961197.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107839.1 → NP_001101309.1 roquin-2

See identical proteins and their annotated locations for NP_001101309.1

Status: PROVISIONAL

Source sequence(s)

CH473983

UniProtKB/TrEMBL

A6JET0

Related

ENSRNOP00000075040.3, ENSRNOT00000078718.3

Conserved Domains (2) summary

pfam00642
Location:411 → 437

zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)

pfam14634
Location:14 → 55

zf-RING_5; zinc-RING finger domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

41531319..41596496 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039105269.2 → XP_038961197.1 roquin-2 isoform X1

UniProtKB/TrEMBL

A0A0G2K9L3

Related

ENSRNOP00000107324.1, ENSRNOT00000165599.1

Conserved Domains (5) summary

PTZ00449
Location:523 → 796

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

COG5063
Location:393 → 457

CTH1; CCCH-type Zn-finger protein [General function prediction only]

cd16638
Location:11 → 54

mRING-HC-C3HC3D_Roquin; Modified RING finger, HC subclass (C3HC3D-type), found in Roquin-1, Roquin-2, and similar proteins

pfam00642
Location:411 → 437

zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)

pfam18386
Location:268 → 323

ROQ_II; Roquin II domain
XM_008761754.4 → XP_008759976.1 roquin-2 isoform X2

UniProtKB/TrEMBL

D3ZBM2

Conserved Domains (2) summary

pfam00642
Location:411 → 437

zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)

pfam14634
Location:14 → 55

zf-RING_5; zinc-RING finger domain