Aplnr apelin receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Aplnrprovided by RGD
Official Full Name: apelin receptorprovided by RGD
Primary source: RGD:621645
See related: EnsemblRapid:ENSRNOG00000009227 AllianceGenome:RGD:621645
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Apj; Agtrl1
Summary: Predicted to enable apelin receptor activity. Involved in G protein-coupled receptor signaling pathway; negative regulation of cAMP-mediated signaling; and regulation of body fluid levels. Located in plasma membrane. Orthologous to human APLNR (apelin receptor). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: 3q24

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (90624055..90627700)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (70217407..70221052)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (72540538..72544183)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gstp1 negatively regulates blood pressure in hypertensive rat via promoting APLNR ubiquitination degradation mediated by Nedd4.
Title: Gstp1 negatively regulates blood pressure in hypertensive rat via promoting APLNR ubiquitination degradation mediated by Nedd4.
The apelin-apela receptor APJ is necessary for formation and healing of ischemia reperfusion-induced gastric ulcer in rats.
Title: The apelin-apela receptor APJ is necessary for formation and healing of ischemia reperfusion-induced gastric ulcer in rats.
ELABELA-APJ-Akt/YAP Signaling Axis: A Novel Mechanism of Aerobic Exercise in Cardioprotection of Myocardial Infarction Rats.
Title: ELABELA-APJ-Akt/YAP Signaling Axis: A Novel Mechanism of Aerobic Exercise in Cardioprotection of Myocardial Infarction Rats.
The effect of experimental varicocele on the apelin and APJ expressions in rat testis tissue.
Title: The effect of experimental varicocele on the apelin and APJ expressions in rat testis tissue.
The enhanced activity of endogenous apelin and APJ receptor in paraventricular nucleus contributes to sympathetic activation in hypertension.
Title: Superoxide anions modulate the performance of apelin in the paraventricular nucleus on sympathetic activity and blood pressure in spontaneously hypertensive rats.
The present study describes the role of spinal apelin in the processing of neuropathic pain induced by chronic constriction of the sciatic nerve, and elucidates receptor and intracellular mechanisms underlying apelin-mediated pain modulation.
Title: Effect of the spinal apelin‑APJ system on the pathogenesis of chronic constriction injury‑induced neuropathic pain in rats.
Apelin- induced recovery of ERK1/2 phosphorylation and Kappa Opioid receptors -APJ dimerization may nominate apelin as a therapeutic goal in treatment of renovascular hypertension.
Title: Heterodimerization of apelin and opioid receptors and cardiac inotropic and lusitropic effects of apelin in 2K1C hypertension: Role of pERK1/2 and PKC.
Apelin receptor and apelin mRNA were significantly increased in the left ventricle following a high fat diet.
Title: The role of apelin in central cardiovascular regulation in rats with post-infarct heart failure maintained on a normal fat or high fat diet.
Electroacupuncture stimulation could alleviate inflammatory pain, at least in part, by restoring apelin and APJ mRNA and protein expression levels, which are downregulated in the complete Freund's adjuvant pain model.
Title: The Effects of Electroacupuncture on the Apelin/APJ System in the Spinal Cord of Rats With Inflammatory Pain.
Apelin-36-[L28C(30kDa-PEG)] provides a starting point for the development of diabetes therapeutics that are devoid of the blood pressure effects associated with canonical APJ activation
Title: Apelin-36 Modulates Blood Glucose and Body Weight Independently of Canonical APJ Receptor Signaling.

Submit: New GeneRIF Correction See all GeneRIFs (33)

General gene information

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Markers

RH137244 (e-PCR)
- UniSTS:219332

UniSTS:234445 (e-PCR)
- UniSTS:234445

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	TAS Traceable Author Statement more info	PubMed
enables apelin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptide binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adult heart development	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in aorta development	ISO Inferred from Sequence Orthology more info
involved_in apelin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in atrioventricular valve development	ISO Inferred from Sequence Orthology more info
involved_in blood vessel development	IBA Inferred from Biological aspect of Ancestor more info
involved_in coronary vasculature development	ISO Inferred from Sequence Orthology more info
involved_in coronary vasculature development	ISS Inferred from Sequence or Structural Similarity more info
involved_in endocardial cushion formation	ISO Inferred from Sequence Orthology more info
involved_in gastrulation	IEA Inferred from Electronic Annotation more info
involved_in heart development	IBA Inferred from Biological aspect of Ancestor more info
involved_in heart development	ISS Inferred from Sequence or Structural Similarity more info
involved_in heart looping	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cAMP-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cAMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cAMP-mediated signaling	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of G protein-coupled receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of release of sequestered calcium ion into cytosol	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of body fluid levels	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of gap junction assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in vascular associated smooth muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in vasculature development	ISO Inferred from Sequence Orthology more info
involved_in vasculogenesis	ISO Inferred from Sequence Orthology more info
involved_in vasculogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in venous blood vessel development	ISO Inferred from Sequence Orthology more info
involved_in ventricular septum morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: apelin receptor

Names: B78; G-protein coupled receptor APJ; GPCR34; angiotensin receptor-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031349.2 → NP_112639.1 apelin receptor

See identical proteins and their annotated locations for NP_112639.1

Status: PROVISIONAL

Source sequence(s)

BC072494

UniProtKB/Swiss-Prot

Q9ESK2, Q9JHG3

UniProtKB/TrEMBL

A6HMT5

Related

ENSRNOP00000012379.4, ENSRNOT00000012379.6

Conserved Domains (1) summary

cd15190
Location:17 → 318

7tmA_Apelin_R; apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors