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    Ablim2 actin binding LIM protein family, member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360958, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ablim2provided by RGD
    Official Full Name
    actin binding LIM protein family, member 2provided by RGD
    Primary source
    RGD:1303094
    See related
    EnsemblRapid:ENSRNOG00000007882 AllianceGenome:RGD:1303094
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in lamellipodium assembly. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in myofibril. Predicted to be active in actin cytoskeleton. Orthologous to human ABLIM2 (actin binding LIM protein family member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 135.8), Brain (RPKM 110.6) and 3 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ablim2 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (79090046..79214986, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (74865409..74990334, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (80044217..80169491, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene actin filament associated protein 1 Neighboring gene uncharacterized LOC134481856 Neighboring gene uncharacterized LOC134481855 Neighboring gene SH3 domain and tetratricopeptide repeats 1 Neighboring gene HtrA serine peptidase 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lamellipodium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in myofibril ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    actin-binding LIM protein 2
    Names
    abLIM-2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001514.2NP_001001514.1  actin-binding LIM protein 2 isoform b

      See identical proteins and their annotated locations for NP_001001514.1

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame two-exon segment in the 3' coding region, compared to variant 1. The resulting isoform (b) lacks an internal segment, compared to isoform a.
      Source sequence(s)
      AJ703893
      UniProtKB/TrEMBL
      A0A140TAH7
      Related
      ENSRNOP00000070221.3, ENSRNOT00000091652.3
      Conserved Domains (6) summary
      cd09327
      Location:2475
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:80135
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:153204
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:212267
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam02209
      Location:539573
      VHP; Villin headpiece domain
      pfam16182
      Location:277537
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
    2. NM_001177695.1NP_001171166.1  actin-binding LIM protein 2 isoform a

      See identical proteins and their annotated locations for NP_001171166.1

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AJ703892
      UniProtKB/Swiss-Prot
      Q6KC50, Q6KC51
      UniProtKB/TrEMBL
      A0A140TAH7
      Related
      ENSRNOP00000055116.6, ENSRNOT00000058315.7
      Conserved Domains (6) summary
      cd09327
      Location:2475
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:80135
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:153204
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:212267
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam02209
      Location:578612
      VHP; Villin headpiece domain
      pfam16182
      Location:277576
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      79090046..79214986 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273369.1XP_063129439.1  actin-binding LIM protein 2 isoform X7

      UniProtKB/TrEMBL
      A0A0H2UHF9
    2. XM_063273367.1XP_063129437.1  actin-binding LIM protein 2 isoform X5

      UniProtKB/TrEMBL
      A0A0H2UHF9
    3. XM_063273363.1XP_063129433.1  actin-binding LIM protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JTB5
      Related
      ENSRNOP00000010482.9, ENSRNOT00000010482.9
    4. XM_063273380.1XP_063129450.1  actin-binding LIM protein 2 isoform X18

      UniProtKB/TrEMBL
      A0A0G2JXC7, A0A140TAH7
    5. XM_063273368.1XP_063129438.1  actin-binding LIM protein 2 isoform X6

      UniProtKB/TrEMBL
      A0A140TAH7
    6. XM_063273371.1XP_063129441.1  actin-binding LIM protein 2 isoform X9

      UniProtKB/TrEMBL
      A0A140TAH7
    7. XM_063273377.1XP_063129447.1  actin-binding LIM protein 2 isoform X15

      UniProtKB/TrEMBL
      A0A0G2JTB5
    8. XM_063273378.1XP_063129448.1  actin-binding LIM protein 2 isoform X16

      UniProtKB/TrEMBL
      A0A140TAH7
    9. XM_063273384.1XP_063129454.1  actin-binding LIM protein 2 isoform X21

      UniProtKB/TrEMBL
      A0A140TAH7
    10. XM_063273385.1XP_063129455.1  actin-binding LIM protein 2 isoform X22

      UniProtKB/TrEMBL
      A0A140TAH7
    11. XM_063273374.1XP_063129444.1  actin-binding LIM protein 2 isoform X12

      UniProtKB/TrEMBL
      A0A0G2JTB5
    12. XM_063273362.1XP_063129432.1  actin-binding LIM protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JTB5
    13. XM_063273364.1XP_063129434.1  actin-binding LIM protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JTB5
    14. XM_063273381.1XP_063129451.1  actin-binding LIM protein 2 isoform X19

      UniProtKB/TrEMBL
      A0A140TAH7
    15. XM_063273379.1XP_063129449.1  actin-binding LIM protein 2 isoform X17

      UniProtKB/TrEMBL
      A0A140TAH7
    16. XM_063273366.1XP_063129436.1  actin-binding LIM protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A0H2UHF9
    17. XM_063273383.1XP_063129453.1  actin-binding LIM protein 2 isoform X20

      UniProtKB/TrEMBL
      A0A140TAH7
    18. XM_063273372.1XP_063129442.1  actin-binding LIM protein 2 isoform X10

      UniProtKB/TrEMBL
      A0A0G2JTB5
    19. XM_063273376.1XP_063129446.1  actin-binding LIM protein 2 isoform X14

      UniProtKB/TrEMBL
      A0A140TAH7
    20. XM_063273373.1XP_063129443.1  actin-binding LIM protein 2 isoform X11

      UniProtKB/TrEMBL
      A0A0H2UHF9
    21. XM_063273375.1XP_063129445.1  actin-binding LIM protein 2 isoform X13

      UniProtKB/TrEMBL
      A0A0H2UHF9
    22. XM_063273370.1XP_063129440.1  actin-binding LIM protein 2 isoform X8

      UniProtKB/TrEMBL
      A0A0G2JTB5
    23. XM_063273387.1XP_063129457.1  actin-binding LIM protein 2 isoform X24

    24. XM_063273386.1XP_063129456.1  actin-binding LIM protein 2 isoform X23

    RNA

    1. XR_010057396.1 RNA Sequence

    2. XR_010057389.1 RNA Sequence

    3. XR_010057397.1 RNA Sequence

    4. XR_010057390.1 RNA Sequence

    5. XR_010057387.1 RNA Sequence

    6. XR_010057388.1 RNA Sequence

    7. XR_010057395.1 RNA Sequence

    8. XR_010057393.1 RNA Sequence

    9. XR_010057392.1 RNA Sequence

    10. XR_010057394.1 RNA Sequence

    11. XR_010057391.1 RNA Sequence