Ahrr aryl-hydrocarbon receptor repressor [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Ahrrprovided by RGD
Full Name: aryl-hydrocarbon receptor repressorprovided by RGD
Primary source: RGD:1559857
See related: EnsemblRapid:ENSRNOG00000014721 AllianceGenome:RGD:1559857
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable nuclear receptor activity and transcription cis-regulatory region binding activity. Involved in nitric oxide metabolic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of aryl hydrocarbon receptor complex. Predicted to be active in nucleus. Biomarker of hypertension. Orthologous to human AHRR (aryl hydrocarbon receptor repressor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 7.0), Uterus (RPKM 5.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1p11

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (30822219..30917251)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (28993634..29088673)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (31603297..31698329)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The expression of AHRR was upregulated in the kidneys of rats with chronic kidney disease.
Title: Influence of AHRR Pro189Ala polymorphism on kidney functions.
the constitutive expression of AhRR mRNA was prominent in males when compared with females in parallel with the sexual difference in AhR
Title: Primary structure and organ-specific expression of the rat aryl hydrocarbon receptor repressor gene.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables transcription cis-regulatory region binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in intracellular receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in nitric oxide metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of protein sumoylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in xenobiotic metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of aryl hydrocarbon receptor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: aryl hydrocarbon receptor repressor

Names: ahR repressor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024285.1 → NP_001019456.1 aryl hydrocarbon receptor repressor

See identical proteins and their annotated locations for NP_001019456.1

Status: PROVISIONAL

Source sequence(s)

AB174900

UniProtKB/Swiss-Prot

Q75NT5

UniProtKB/TrEMBL

A6JUU9

Related

ENSRNOP00000019806.2, ENSRNOT00000019806.5

Conserved Domains (3) summary

smart00353
Location:35 → 86

HLH; helix loop helix domain

smart00091
Location:108 → 174

PAS; PAS domain

pfam00989
Location:108 → 173

PAS; PAS fold