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    Atp8a2 ATPase phospholipid transporting 8A2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 691889, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Atp8a2provided by RGD
    Official Full Name
    ATPase phospholipid transporting 8A2provided by RGD
    Primary source
    RGD:1594597
    See related
    EnsemblRapid:ENSRNOG00000008053 AllianceGenome:RGD:1594597
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable aminophospholipid flippase activity. Acts upstream of or within neuron projection development. Predicted to be located in several cellular components, including Golgi apparatus; endosome; and nucleoplasm. Predicted to be part of phospholipid-translocating ATPase complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 4. Orthologous to human ATP8A2 (ATPase phospholipid transporting 8A2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 50.5), Testes (RPKM 50.3) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Atp8a2 in Genome Data Viewer
    Location:
    15p12
    Exon count:
    49
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (37993507..38526408, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (33817309..34350193, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (39955689..40488737, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S9, pseudogene 9 Neighboring gene eukaryotic translation initiation factor 4B, pseudogene 1 Neighboring gene shisa family member 2 Neighboring gene uncharacterized LOC134481976 Neighboring gene ETS-related transcription factor Elf-2 pseudogene Neighboring gene uncharacterized LOC103693635 Neighboring gene nucleoporin 58 Neighboring gene myotubularin related protein 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phospholipid flippase ATP8A2 is required for normal visual and auditory function and photoreceptor and spiral ganglion cell survival. Coleman JA, et al. J Cell Sci, 2014 Mar 1. PMID 24413176, Free PMC Article
    2. Mutations in a P-type ATPase gene cause axonal degeneration. Zhu X, et al. PLoS Genet, 2012. PMID 22912588, Free PMC Article
    3. P4-ATPase ATP8A2 acts in synergy with CDC50A to enhance neurite outgrowth. Xu Q, et al. FEBS Lett, 2012 Jun 21. PMID 22641037
    4. Genetic and age related models of neurodegeneration in mice: dystrophic axons. Bronson RT, et al. J Neurogenet, 1992 May. PMID 1634998
    5. Heteromeric interactions required for abundance and subcellular localization of human CDC50 proteins and class 1 P4-ATPases. van der Velden LM, et al. J Biol Chem, 2010 Dec 17. PMID 20947505, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled intramembrane lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aminophospholipid flippase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in aminophospholipid translocation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within axonogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in detection of light stimulus involved in visual perception ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within determination of adult lifespan ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within eating behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in inner ear morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within involuntary skeletal muscle contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neurofilament cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuromuscular process controlling posture ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within neuron development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phospholipid translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of phospholipid translocation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to auditory stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retina layer formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within skin development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of phospholipid-translocating ATPase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phospholipid-transporting ATPase IB
    Names
    ATPase, aminophospholipid transporter, class I, type 8A, member 2
    NP_001414379.1
    XP_003751540.1
    XP_038949921.1
    XP_038949922.1
    XP_038949924.1
    XP_038949925.1
    XP_038949926.1
    XP_038949927.1
    XP_038949928.1
    XP_038949929.1
    XP_038949930.1
    XP_038949931.1
    XP_038949932.1
    XP_038949933.1
    XP_063130743.1
    XP_063130744.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427450.1 → NP_001414379.1  phospholipid-transporting ATPase IB

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A8I5ZQP3, A0A8I6AGF0
      Related
      ENSRNOP00000095034.2, ENSRNOT00000116305.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      37993507..38526408 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093999.2 → XP_038949927.1  phospholipid-transporting ATPase IB isoform X5

      UniProtKB/TrEMBL
      A0A8I6AGF0
      Conserved Domains (1) summary
      TIGR01652
      Location:28 → 1078
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

    2. XM_039093996.2 → XP_038949924.1  phospholipid-transporting ATPase IB isoform X5

      UniProtKB/TrEMBL
      A0A8I6AGF0
      Conserved Domains (1) summary
      TIGR01652
      Location:28 → 1078
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

    3. XM_039093997.2 → XP_038949925.1  phospholipid-transporting ATPase IB isoform X5

      UniProtKB/TrEMBL
      A0A8I6AGF0
      Conserved Domains (1) summary
      TIGR01652
      Location:28 → 1078
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

    4. XM_039094002.2 → XP_038949930.1  phospholipid-transporting ATPase IB isoform X5

      UniProtKB/TrEMBL
      A0A8I6AGF0
      Conserved Domains (1) summary
      TIGR01652
      Location:28 → 1078
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

    5. XM_039094003.1 → XP_038949931.1  phospholipid-transporting ATPase IB isoform X6

      UniProtKB/TrEMBL
      A0A8I6AGF0
      Conserved Domains (1) summary
      TIGR01652
      Location:68 → 1043
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

    6. XM_003751492.5 → XP_003751540.1  phospholipid-transporting ATPase IB isoform X3

      UniProtKB/TrEMBL
      A0A8I6AGF0
      Related
      ENSRNOP00000080718.2, ENSRNOT00000099280.2
      Conserved Domains (6) summary
      TIGR01652
      Location:68 → 1106
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:125 → 342
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:506 → 604
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:57 → 119
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:848 → 1099
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:816 → 845
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    7. XM_039093993.1 → XP_038949921.1  phospholipid-transporting ATPase IB isoform X1

      UniProtKB/TrEMBL
      A0A8I6A3Z6, A0A8I6AGF0
      Conserved Domains (1) summary
      TIGR01652
      Location:68 → 1118
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

    8. XM_039093998.1 → XP_038949926.1  phospholipid-transporting ATPase IB isoform X5

      UniProtKB/TrEMBL
      A0A8I6AGF0
      Conserved Domains (1) summary
      TIGR01652
      Location:28 → 1078
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

    9. XM_039093994.2 → XP_038949922.1  phospholipid-transporting ATPase IB isoform X2

      UniProtKB/TrEMBL
      A0A8I6GLF5
      Conserved Domains (1) summary
      TIGR01652
      Location:67 → 1117
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

    10. XM_039094000.2 → XP_038949928.1  phospholipid-transporting ATPase IB isoform X5

      UniProtKB/TrEMBL
      A0A8I6AGF0
      Conserved Domains (1) summary
      TIGR01652
      Location:28 → 1078
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

    11. XM_063274673.1 → XP_063130743.1  phospholipid-transporting ATPase IB isoform X4

      UniProtKB/TrEMBL
      A0A8I6AGF0

    12. XM_039094001.2 → XP_038949929.1  phospholipid-transporting ATPase IB isoform X5

      UniProtKB/TrEMBL
      A0A8I6AGF0
      Conserved Domains (1) summary
      TIGR01652
      Location:28 → 1078
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

    13. XM_063274674.1 → XP_063130744.1  phospholipid-transporting ATPase IB isoform X7

      UniProtKB/TrEMBL
      A0A8I6GLF5

    14. XM_039094004.2 → XP_038949932.1  phospholipid-transporting ATPase IB isoform X8

      Conserved Domains (1) summary
      TIGR01652
      Location:68 → 806
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

    15. XM_039094005.2 → XP_038949933.1  phospholipid-transporting ATPase IB isoform X9

      Conserved Domains (1) summary
      TIGR01652
      Location:68 → 760
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    Nucleotide Protein Strain
    Heading Accession and Version

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