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    Rnf126 ring finger protein 126 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314613, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rnf126provided by RGD
    Official Full Name
    ring finger protein 126provided by RGD
    Primary source
    RGD:1306011
    See related
    EnsemblRapid:ENSRNOG00000009028 AllianceGenome:RGD:1306011
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable epidermal growth factor receptor binding activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including positive regulation of double-strand break repair via homologous recombination; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human RNF126 (ring finger protein 126). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 203.2), Brain (RPKM 71.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rnf126 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (10590013..10597585)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (9939359..9946963)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (12820796..12828325)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene serine protease 57 Neighboring gene follistatin like 3 Neighboring gene fibroblast growth factor 22 Neighboring gene RNA polymerase mitochondrial

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. HSF1 phosphorylation by ERK/GSK3 suppresses RNF126 to sustain IGF-IIR expression for hypertension-induced cardiomyocyte hypertrophy. Huang CY, et al. J Cell Physiol, 2018 Feb. PMID 28383811
    2. The ubiquitin ligase RNF126 regulates the retrograde sorting of the cation-independent mannose 6-phosphate receptor. Smith CJ, et al. Exp Cell Res, 2014 Jan 15. PMID 24275455
    3. E3 ubiquitin ligase RNF126 promotes cancer cell proliferation by targeting the tumor suppressor p21 for ubiquitin-mediated degradation. Zhi X, et al. Cancer Res, 2013 Jan 1. PMID 23026136
    4. The E3 ubiquitin ligases RNF126 and Rabring7 regulate endosomal sorting of the epidermal growth factor receptor. Smith CJ, et al. J Cell Sci, 2013 Mar 15. PMID 23418353
    5. Cytosolic quality control of mislocalized proteins requires RNF126 recruitment to Bag6. Rodrigo-Brenni MC, et al. Mol Cell, 2014 Jul 17. PMID 24981174, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Angiotensin II activates ERK/GSK3 to phosphorylate HSF1, resulting in RNF126 degradation, which stabilizes IGF-IIR protein expression and eventually results in cardiac hypertrophy.
      Title: HSF1 phosphorylation by ERK/GSK3 suppresses RNF126 to sustain IGF-IIR expression for hypertension-induced cardiomyocyte hypertrophy.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Clone Names

    • MGC124770

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables epidermal growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasm protein quality control by the ubiquitin-proteasome system ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K27-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K29-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K63-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RNF126
    NP_001028874.1
    XP_006240961.1
    XP_017450300.1
    XP_063119479.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033702.1 → NP_001028874.1  E3 ubiquitin-protein ligase RNF126

      See identical proteins and their annotated locations for NP_001028874.1

      Status: PROVISIONAL

      Source sequence(s)
      BC099810
      UniProtKB/TrEMBL
      A0A8I6GM09, F7ESD4, Q499Q1
      Conserved Domains (2) summary
      pfam13639
      Location:245 → 287
      zf-RING_2; Ring finger domain
      pfam14369
      Location:10 → 40
      zinc_ribbon_9; zinc-ribbon

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      10590013..10597585
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017594811.3 → XP_017450300.1  E3 ubiquitin-protein ligase RNF126 isoform X2

    2. XM_063263409.1 → XP_063119479.1  E3 ubiquitin-protein ligase RNF126 isoform X3

    3. XM_006240899.4 → XP_006240961.1  E3 ubiquitin-protein ligase RNF126 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GM09
      Related
      ENSRNOP00000012317.7, ENSRNOT00000012317.8
      Conserved Domains (2) summary
      pfam13639
      Location:230 → 272
      zf-RING_2; Ring finger domain
      pfam14369
      Location:10 → 40
      zinc_ribbon_9; zinc-ribbon
    Nucleotide Protein Strain
    Heading Accession and Version

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