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    Far1 fatty acyl CoA reductase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293173, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Far1provided by RGD
    Official Full Name
    fatty acyl CoA reductase 1provided by RGD
    Primary source
    RGD:1306647
    See related
    EnsemblRapid:ENSRNOG00000013176 AllianceGenome:RGD:1306647
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mlstd2
    Summary
    Predicted to enable alcohol-forming very long-chain fatty acyl-CoA reductase activity. Predicted to be involved in several processes, including ether lipid biosynthetic process; long-chain fatty-acyl-CoA metabolic process; and wax biosynthetic process. Predicted to be located in peroxisomal membrane. Predicted to be active in peroxisome. Human ortholog(s) of this gene implicated in rhizomelic chondrodysplasia punctate type 4. Orthologous to human FAR1 (fatty acyl-CoA reductase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 225.1), Lung (RPKM 188.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Far1 in Genome Data Viewer
    Location:
    1q33
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (177078973..177140363)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (167644622..167705868)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (178351674..178412838)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene parathyroid hormone Neighboring gene enolase 1, pseudogene 9 Neighboring gene cytochrome c, somatic-like Neighboring gene uncharacterized LOC102548137 Neighboring gene methionyl aminopeptidase 2, pseudogene 3 Neighboring gene uncharacterized LOC134484911

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The peroxisomal enzyme, FAR1, is induced during ER stress in an ATF6-dependent manner in cardiac myocytes. Marsh KG, et al. Am J Physiol Heart Circ Physiol, 2021 May 1. PMID 33666503, Free PMC Article
    2. Posttranslational regulation of fatty acyl-CoA reductase 1, Far1, controls ether glycerophospholipid synthesis. Honsho M, et al. J Biol Chem, 2010 Mar 19. PMID 20071337, Free PMC Article
    3. Topogenesis and homeostasis of fatty acyl-CoA reductase 1. Honsho M, et al. J Biol Chem, 2013 Nov 29. PMID 24108123, Free PMC Article
    4. Mammalian wax biosynthesis. I. Identification of two fatty acyl-Coenzyme A reductases with different substrate specificities and tissue distributions. Cheng JB, et al. J Biol Chem, 2004 Sep 3. PMID 15220348, Free PMC Article
    5. Mammalian wax biosynthesis. II. Expression cloning of wax synthase cDNAs encoding a member of the acyltransferase enzyme family. Cheng JB, et al. J Biol Chem, 2004 Sep 3. PMID 15220349, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The peroxisomal enzyme, FAR1, is induced during ER stress in an ATF6-dependent manner in cardiac myocytes.
      Title: The peroxisomal enzyme, FAR1, is induced during ER stress in an ATF6-dependent manner in cardiac myocytes.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables alcohol-forming long-chain fatty acyl-CoA reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alcohol-forming long-chain fatty acyl-CoA reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables alcohol-forming long-chain fatty acyl-CoA reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables alcohol-forming very long-chain fatty acyl-CoA reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alcohol-forming very long-chain fatty acyl-CoA reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alcohol-forming very long-chain fatty acyl-CoA reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ether lipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ether lipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ether lipid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in fatty acid derivative metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycerophospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycerophospholipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in long-chain fatty-acyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-chain fatty-acyl-CoA metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in long-chain fatty-acyl-CoA metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in wax biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in wax biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in wax biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in peroxisomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    fatty acyl-CoA reductase 1
    Names
    male sterility domain containing 2
    male sterility domain-containing protein 2
    NP_001011933.1
    XP_006230079.1
    XP_006230080.1
    XP_006230082.1
    XP_038962380.1
    XP_038962381.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011933.1 → NP_001011933.1  fatty acyl-CoA reductase 1

      See identical proteins and their annotated locations for NP_001011933.1

      Status: PROVISIONAL

      Source sequence(s)
      BC082015
      UniProtKB/Swiss-Prot
      Q66H50
      UniProtKB/TrEMBL
      A6I889
      Conserved Domains (3) summary
      cd05236
      Location:11 → 330
      FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
      PLN02996
      Location:2 → 446
      PLN02996; fatty acyl-CoA reductase
      pfam03015
      Location:371 → 447
      Sterile; Male sterility protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      177078973..177140363
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006230017.5 → XP_006230079.1  fatty acyl-CoA reductase 1 isoform X1

      See identical proteins and their annotated locations for XP_006230079.1

      UniProtKB/TrEMBL
      A0A096MJW2, A6I887
      Related
      ENSRNOP00000018532.8, ENSRNOT00000018532.8
      Conserved Domains (2) summary
      cd05236
      Location:11 → 330
      FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
      pfam03015
      Location:357 → 447
      Sterile; Male sterility protein

    2. XM_039106452.2 → XP_038962380.1  fatty acyl-CoA reductase 1 isoform X1

      UniProtKB/TrEMBL
      A0A096MJW2, A6I887
      Conserved Domains (2) summary
      cd05236
      Location:11 → 330
      FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
      pfam03015
      Location:357 → 447
      Sterile; Male sterility protein

    3. XM_006230020.5 → XP_006230082.1  fatty acyl-CoA reductase 1 isoform X2

      See identical proteins and their annotated locations for XP_006230082.1

      UniProtKB/Swiss-Prot
      Q66H50
      UniProtKB/TrEMBL
      A6I889
      Related
      ENSRNOP00000068284.2, ENSRNOT00000076430.4
      Conserved Domains (3) summary
      cd05236
      Location:11 → 330
      FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
      PLN02996
      Location:2 → 446
      PLN02996; fatty acyl-CoA reductase
      pfam03015
      Location:371 → 447
      Sterile; Male sterility protein

    4. XM_039106453.2 → XP_038962381.1  fatty acyl-CoA reductase 1 isoform X3

      Conserved Domains (1) summary
      cd05236
      Location:11 → 319
      FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs

    5. XM_006230018.5 → XP_006230080.1  fatty acyl-CoA reductase 1 isoform X1

      See identical proteins and their annotated locations for XP_006230080.1

      UniProtKB/TrEMBL
      A0A096MJW2, A6I887
      Conserved Domains (2) summary
      cd05236
      Location:11 → 330
      FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
      pfam03015
      Location:357 → 447
      Sterile; Male sterility protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q66H50.1 GenPept UniProtKB/Swiss-Prot:Q66H50

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