Ptprk protein tyrosine phosphatase, receptor type, K [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ptprkprovided by RGD
Official Full Name: protein tyrosine phosphatase, receptor type, Kprovided by RGD
Primary source: RGD:619706
See related: EnsemblRapid:ENSRNOG00000047605 AllianceGenome:RGD:619706
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rptpk
Summary: Predicted to enable several functions, including beta-catenin binding activity; gamma-catenin binding activity; and protein tyrosine phosphatase activity. Involved in T cell differentiation; cell adhesion; and neuron projection development. Predicted to be located in several cellular components, including leading edge membrane; neuronal cell body; and photoreceptor outer segment. Orthologous to human PTPRK (protein tyrosine phosphatase receptor type K). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 161.2), Lung (RPKM 125.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1p12

Exon count:: 37

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (18557091..19056297, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (16738896..17236687, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (17445052..18058266, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Contiguous gene deletion of Ptprk and Themis causes T-helper immunodeficiency (thid) in the LEC rat.
Title: Contiguous gene deletion of Ptprk and Themis causes T-helper immunodeficiency (thid) in the LEC rat.
The Ptprk gene is responsible for the thid mutation in the LEC rat. Results further suggest that RPTPkappa plays a critical role in the development of CD4 SP cells in the thymus.
Title: A deletion mutation of the protein tyrosine phosphatase kappa (Ptprk) gene is responsible for T-helper immunodeficiency (thid) in the LEC rat.
Ptprk appears to function in parallel with or downstream of Th-POK/cKrox (also known as ZBTB7B), a master regulator of T cell lineage decision.
Title: Maturational arrest of thymocyte development is caused by a deletion in the receptor-like protein tyrosine phosphatase kappa gene in LEC rats.

Submit: New GeneRIF Correction

General gene information

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Markers

AU028812 (e-PCR)
- UniSTS:111962

RH144364 (e-PCR)
- UniSTS:233609

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables beta-catenin binding	ISO Inferred from Sequence Orthology more info
enables gamma-catenin binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in T cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cellular response to UV	ISO Inferred from Sequence Orthology more info
involved_in cellular response to reactive oxygen species	ISO Inferred from Sequence Orthology more info
involved_in focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of keratinocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein localization to cell surface	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	ISO Inferred from Sequence Orthology more info
involved_in transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in leading edge membrane	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in photoreceptor outer segment	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: receptor-type tyrosine-protein phosphatase kappa

Names: protein tyrosine phosphatase, receptor type, K, extracellular region; receptor-like protein tyrosine phosphatase kappa extracellular region (RPTPK)

NP_001025073.2

EC 3.1.3.48

XP_063121937.1

EC 3.1.3.48

XP_063121938.1

EC 3.1.3.48

XP_063121941.1

EC 3.1.3.48

XP_063121942.1

EC 3.1.3.48

XP_063121945.1

EC 3.1.3.48

XP_063121947.1

EC 3.1.3.48

XP_063121950.1

EC 3.1.3.48

XP_063121954.1

EC 3.1.3.48

XP_063121957.1

EC 3.1.3.48

XP_063121959.1

EC 3.1.3.48

XP_063121968.1

EC 3.1.3.48

XP_063121975.1

EC 3.1.3.48

XP_063121976.1

EC 3.1.3.48

XP_063121977.1

EC 3.1.3.48

XP_063121983.1

EC 3.1.3.48

XP_063121989.1

EC 3.1.3.48

XP_063121997.1

EC 3.1.3.48

XP_063122006.1

EC 3.1.3.48

XP_063122009.1

EC 3.1.3.48

XP_063122013.1

EC 3.1.3.48

XP_063122014.1

EC 3.1.3.48

XP_063122015.1

EC 3.1.3.48

XP_063122018.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001029902.2 → NP_001025073.2 receptor-type tyrosine-protein phosphatase kappa precursor

See identical proteins and their annotated locations for NP_001025073.2

Status: PROVISIONAL

Source sequence(s)

AB297790

UniProtKB/TrEMBL

A5I9F0, F1LPL4

Conserved Domains (9) summary

cd06263
Location:35 → 191

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

smart00137
Location:31 → 191

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00194
Location:886 → 1140

PTPc; Protein tyrosine phosphatase, catalytic domain

smart00410
Location:201 → 287

IG_like; Immunoglobulin like

cd00047
Location:913 → 1140

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:487 → 588

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:293 → 371

fn3; Fibronectin type III domain

pfam00102
Location:1200 → 1434

Y_phosphatase; Protein-tyrosine phosphatase

cl11960
Location:203 → 283

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

18557091..19056297 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063265927.1 → XP_063121997.1 receptor-type tyrosine-protein phosphatase kappa isoform X17
XM_063265913.1 → XP_063121983.1 receptor-type tyrosine-protein phosphatase kappa isoform X15
XM_063265905.1 → XP_063121975.1 receptor-type tyrosine-protein phosphatase kappa isoform X12
XM_063265948.1 → XP_063122018.1 receptor-type tyrosine-protein phosphatase kappa isoform X23
XM_063265880.1 → XP_063121950.1 receptor-type tyrosine-protein phosphatase kappa isoform X7
XM_063265868.1 → XP_063121938.1 receptor-type tyrosine-protein phosphatase kappa isoform X2
XM_063265919.1 → XP_063121989.1 receptor-type tyrosine-protein phosphatase kappa isoform X16
XM_063265907.1 → XP_063121977.1 receptor-type tyrosine-protein phosphatase kappa isoform X14
XM_063265906.1 → XP_063121976.1 receptor-type tyrosine-protein phosphatase kappa isoform X13
XM_063265898.1 → XP_063121968.1 receptor-type tyrosine-protein phosphatase kappa isoform X11

Related

ENSRNOP00000105620.1, ENSRNOT00000150254.1
XM_063265887.1 → XP_063121957.1 receptor-type tyrosine-protein phosphatase kappa isoform X9
XM_063265945.1 → XP_063122015.1 receptor-type tyrosine-protein phosphatase kappa isoform X22

Related

ENSRNOP00000108431.1, ENSRNOT00000156515.1
XM_063265877.1 → XP_063121947.1 receptor-type tyrosine-protein phosphatase kappa isoform X6

Related

ENSRNOP00000100835.1, ENSRNOT00000121655.1
XM_063265889.1 → XP_063121959.1 receptor-type tyrosine-protein phosphatase kappa isoform X10

Related

ENSRNOP00000107475.1, ENSRNOT00000121569.1
XM_063265884.1 → XP_063121954.1 receptor-type tyrosine-protein phosphatase kappa isoform X8
XM_063265875.1 → XP_063121945.1 receptor-type tyrosine-protein phosphatase kappa isoform X5
XM_063265871.1 → XP_063121941.1 receptor-type tyrosine-protein phosphatase kappa isoform X3

Related

ENSRNOP00000104699.1, ENSRNOT00000132092.1
XM_063265872.1 → XP_063121942.1 receptor-type tyrosine-protein phosphatase kappa isoform X4
XM_063265867.1 → XP_063121937.1 receptor-type tyrosine-protein phosphatase kappa isoform X1

Related

ENSRNOP00000099423.1, ENSRNOT00000151000.1
XM_063265943.1 → XP_063122013.1 receptor-type tyrosine-protein phosphatase kappa isoform X20

UniProtKB/TrEMBL

A6JPF0
XM_063265939.1 → XP_063122009.1 receptor-type tyrosine-protein phosphatase kappa isoform X19

UniProtKB/TrEMBL

A6JPF0
XM_063265936.1 → XP_063122006.1 receptor-type tyrosine-protein phosphatase kappa isoform X18

UniProtKB/TrEMBL

A6JPF0
XM_063265944.1 → XP_063122014.1 receptor-type tyrosine-protein phosphatase kappa isoform X21