U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Mtif2 mitochondrial translational initiation factor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305606, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Mtif2provided by RGD
    Official Full Name
    mitochondrial translational initiation factor 2provided by RGD
    Primary source
    RGD:1303046
    See related
    EnsemblRapid:ENSRNOG00000004161 AllianceGenome:RGD:1303046
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ribosomal small subunit binding activity and translation initiation factor activity. Predicted to be involved in mitochondrial translational initiation and ribosome disassembly. Predicted to be located in nucleoplasm. Predicted to be active in mitochondrion. Orthologous to human MTIF2 (mitochondrial translational initiation factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 134.3), Thymus (RPKM 104.2) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Mtif2 in Genome Data Viewer
    Location:
    14q22
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (107465719..107486663)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (103265808..103285733)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (113946084..113965574)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene coiled coil domain containing 88A Neighboring gene large ribosomal subunit protein eL19-like Neighboring gene prolyl-tRNA synthetase associated domain containing 1 Neighboring gene ribosomal protein S27a Neighboring gene clathrin heavy chain linker domain containing 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The human mitochondrial translation initiation factor 2 gene (MTIF2): transcriptional analysis and identification of a pseudogene. Overman RG Jr, et al. Biochim Biophys Acta, 2003 Aug 25. PMID 12932832
    2. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC94962

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosomal small subunit binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables translation factor activity, RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ribosome disassembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in translation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in translational initiation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    translation initiation factor IF-2, mitochondrial

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004254.1 → NP_001004254.1  translation initiation factor IF-2, mitochondrial

      See identical proteins and their annotated locations for NP_001004254.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079421
      UniProtKB/TrEMBL
      A0A8I5Y2H0, F7FDM3, Q68FQ5
      Related
      ENSRNOP00000005834.7, ENSRNOT00000005834.8
      Conserved Domains (1) summary
      cl30717
      Location:72 → 720
      InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      107465719..107486663
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039092122.2 → XP_038948050.1  translation initiation factor IF-2, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y2H0, F7FDM3, Q68FQ5
      Conserved Domains (1) summary
      cl30717
      Location:72 → 720
      InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]

    2. XM_039092118.2 → XP_038948046.1  translation initiation factor IF-2, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y2H0, F7FDM3, Q68FQ5
      Conserved Domains (1) summary
      cl30717
      Location:72 → 720
      InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]

    3. XM_039092124.2 → XP_038948052.1  translation initiation factor IF-2, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y2H0, F7FDM3, Q68FQ5
      Conserved Domains (1) summary
      cl30717
      Location:72 → 720
      InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]

    4. XM_063273288.1 → XP_063129358.1  translation initiation factor IF-2, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y2H0, F7FDM3, Q68FQ5

    5. XM_039092121.2 → XP_038948049.1  translation initiation factor IF-2, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y2H0, F7FDM3, Q68FQ5
      Conserved Domains (1) summary
      cl30717
      Location:72 → 720
      InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]

    6. XM_039092126.2 → XP_038948054.1  translation initiation factor IF-2, mitochondrial isoform X2

      Conserved Domains (1) summary
      cl30717
      Location:72 → 437
      InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]

    7. XM_039092127.2 → XP_038948055.1  translation initiation factor IF-2, mitochondrial isoform X3

      Conserved Domains (1) summary
      cl30717
      Location:3 → 389
      InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools