Faah fatty acid amide hydrolase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Faahprovided by RGD
Official Full Name: fatty acid amide hydrolaseprovided by RGD
Primary source: RGD:61808
See related: EnsemblRapid:ENSRNOG00000045949 AllianceGenome:RGD:61808
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables several functions, including hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; identical protein binding activity; and monoacylglycerol lipase activity. Involved in fatty acid catabolic process; monoacylglycerol catabolic process; and positive regulation of vasoconstriction. Located in organelle membrane. Is active in postsynapse and presynapse. Human ortholog(s) of this gene implicated in obesity and substance-related disorder. Orthologous to human FAAH (fatty acid amide hydrolase). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: Note: This locus corresponds to the rat Faah gene and shares synteny with Faah in mouse and human. Rat Faah was previously associated with GeneID: 29347, which may correspond to a duplication of this locus in the rat assembly. [19 Mar 2019]; Note: This locus was previously annotated as the rat Faah gene, which is now associated with GeneID: 100911581. GeneID: 100911581 shares synteny with Faah in mouse and human. This locus corresponds to a duplication of Faah in the rat assembly. [06 Jul 2022]
Expression: Biased expression in Liver (RPKM 204.3), Brain (RPKM 57.9) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q35

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (134716545..134735396, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (129479774..129499018, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (134852899..134872095, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fatty Acid Amide Hydrolase and Cannabinoid Receptor Type 1 Genes Regulation is Modulated by Social Isolation in Rats.
Title: Fatty Acid Amide Hydrolase and Cannabinoid Receptor Type 1 Genes Regulation is Modulated by Social Isolation in Rats.
Fatty acid amide hydrolase activity in the dorsal periaqueductal gray attenuates neuropathic pain and associated dysautonomia.
Title: Fatty acid amide hydrolase activity in the dorsal periaqueductal gray attenuates neuropathic pain and associated dysautonomia.
Pregnant rat maternal under-nutrition resulted in a striking decrease in body weight of weaning rats and expression of this protein.
Title: Effect of maternal under-nutrition on pup body weight and hypothalamic endocannabinoid levels.
study of ovary for presence of CB(1) and CB(2) receptors and fatty acid amide hydrolase; FAAH codistributed with CB(2) receptor in oocytes and luteal cells; it was present in ovarian surface epithelium and cells adjacent to developing preantral follicles
Title: Temporal and spatial distribution of the cannabinoid receptors (CB1, CB2) and fatty acid amide hydroxylase in the rat ovary.
critical role for FAAH, the endocannabinoid system and BDNF in the genetic predisposition to depressive-like behavior in WKY rats
Title: Dysfunction in fatty acid amide hydrolase is associated with depressive-like behavior in Wistar Kyoto rats.
FAAH was expressed in bladder mucosa. The FAAH inhibitor oleoyl ethyl amide altered urodynamic parameters that reflect sensory functions of micturition in rats.
Title: Expression of fatty acid amide hydrolase (FAAH) in human, mouse, and rat urinary bladder and effects of FAAH inhibition on bladder function in awake rats.
FAAH's capacity to hydrolyze the substrates N-acyl ethanolamine and N-acyl taurine is successfully uncoupled by a single glycine-to-aspartate (G268D) point mutation in the FAAH active site. The altered substrate selectivity is preserved in living cells.
Title: Structure-based design of a FAAH variant that discriminates between the N-acyl ethanolamine and taurine families of signaling lipids.
During postnatal development of the hippocampus, the spatio-temporal expression of FAAH correlates well with the general pattern of neuronal maturation.
Title: The spatial and temporal pattern of fatty acid amide hydrolase expression in rat hippocampus during postnatal development.
The hypotensive effect of FAAH inhibitor URB597 is independent of KCa2.3/KCa3.1-endothelium dependent hyperpolarization-type relaxation.
Title: The influence of DOCA-salt hypertension and chronic administration of the FAAH inhibitor URB597 on K(Ca)2.3/K(Ca)3.1-EDH-type relaxation in rat small mesenteric arteries.
the current findings support the therapeutic potential of FAAH and monoacylglycerol lipase inhibitors as a novel pharmacotherapy for pain
Title: Endocannabinoid modulation by FAAH and monoacylglycerol lipase within the analgesic circuitry of the periaqueductal grey.

Submit: New GeneRIF Correction See all GeneRIFs (38)

General gene information

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Markers

RH133581 (e-PCR)
- UniSTS:216864

MARC_7381-7382:996687840:1 (e-PCR)
- UniSTS:269778

RH131970 (e-PCR)
- UniSTS:215253

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables amidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables amidase activity	IDA Inferred from Direct Assay more info	PubMed
enables fatty acid amide hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fatty acid amide hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables fatty acid amide hydrolase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables fatty acid amide hydrolase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on ester bonds	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables lipid binding	IDA Inferred from Direct Assay more info	PubMed
enables monoacylglycerol lipase activity	IDA Inferred from Direct Assay more info	PubMed
enables monoacylglycerol lipase activity	ISO Inferred from Sequence Orthology more info
enables phospholipid binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in fatty acid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in fatty acid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in fatty acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoacylglycerol catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of vasoconstriction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in organelle membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: fatty-acid amide hydrolase 1

Names: anandamide amidase; anandamide amidohydrolase 1; fatty acid ester hydrolase; oleamide hydrolase 1

NP_001356055.1

EC 3.5.1.99

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001369126.1 → NP_001356055.1 fatty-acid amide hydrolase 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P97612, Q5BKA3

UniProtKB/TrEMBL

A0A8L2Q8I2, A6JZ57

Related

ENSRNOP00000015667.6, ENSRNOT00000015667.9

Conserved Domains (1) summary

cl18951
Location:95 → 562

Amidase