Bex1 brain expressed X-linked 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bex1provided by RGD
Official Full Name: brain expressed X-linked 1provided by RGD
Primary source: RGD:1564643
See related: EnsemblRapid:ENSRNOG00000033844 AllianceGenome:RGD:1564643
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Bex; Bex2; Bex1h
Summary: Predicted to enable molecular function inhibitor activity and signaling receptor binding activity. Acts upstream of or within negative regulation of neuron differentiation and positive regulation of neuroblast proliferation. Located in cytoplasm and nucleus. Orthologous to human BEX1 (brain expressed X-linked 1). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: Note: The Bex1 and Bex2 genes appear to have undergone gene conversion, exchanging bits of coding sequence with each other. This complicates determination of orthologs in other species. For this reason, gene name assignments may not be consistent between species. [06 Dec 2023]
Expression: Biased expression in Thymus (RPKM 183.5), Brain (RPKM 179.3) and 7 other tissues See more
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Genomic context

Location:: Xq32

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (104010639..104012143, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (99219014..99220518, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Bex1 may play the neuronal anti-apoptosis role following intracerebral hemorrhage (ICH), implying a novel molecular target for the therapy of ICH.
Title: Bex1 attenuates neuronal apoptosis in rat intracerebral hemorrhage model.
Bex family members play important roles in the formation of protein network hubs.
Title: Brain expressed and X-linked (Bex) proteins are intrinsically disordered proteins (IDPs) and form new signaling hubs.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126864 (e-PCR)
- UniSTS:209752

RH134506 (e-PCR)
- UniSTS:217786

RH130926 (e-PCR)
- UniSTS:214210

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular function inhibitor activity	IEA Inferred from Electronic Annotation more info
enables molecular function inhibitor activity	ISO Inferred from Sequence Orthology more info
enables molecular function inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within axon development	ISO Inferred from Sequence Orthology more info
involved_in axon regeneration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within axon regeneration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of neuroblast proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein BEX1

Names: EG2RVC; brain expressed X-linked 2; brain expressed gene 1; brain-expressed X-linked protein 1 homolog; brain-expressed X-linked protein 2 homolog; protein BEX2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.