Eci3 enoyl-Coenzyme A delta isomerase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Eci3provided by RGD
Official Full Name: enoyl-Coenzyme A delta isomerase 3provided by RGD
Primary source: RGD:1310224
See related: EnsemblRapid:ENSRNOG00000029549 AllianceGenome:RGD:1310224
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1310224
Summary: Predicted to enable delta(3)-delta(2)-enoyl-CoA isomerase activity and fatty-acyl-CoA binding activity. Predicted to be located in peroxisome. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 2044.2), Liver (RPKM 2012.4) and 3 other tissues See more
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Genomic context

Location:: 17p12

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (30127425..30149249)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (29921962..29943864)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (30617382..30639068)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Eci3 specifically evolved in rodents after gene duplication of Eci2 and is localized to the peroxisomes
Title: Identification and characterization of Eci3, a murine kidney-specific Δ3,Δ2-enoyl-CoA isomerase.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables delta(3)-delta(2)-enoyl-CoA isomerase activity	IEA Inferred from Electronic Annotation more info
enables fatty-acyl-CoA binding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in peroxisome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: enoyl-Coenzyme A delta isomerase 3

NP_001009275.1

EC 5.3.3.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009275.1 → NP_001009275.1 enoyl-Coenzyme A delta isomerase 3

See identical proteins and their annotated locations for NP_001009275.1

Status: PROVISIONAL

Source sequence(s)

BC088178

UniProtKB/TrEMBL

A0A0G2K277, Q5M884

Related

ENSRNOP00000050206.2, ENSRNOT00000048923.6

Conserved Domains (1) summary

cl23717
Location:46 → 301

crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...