Tln1 talin 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tln1provided by RGD
Official Full Name: talin 1provided by RGD
Primary source: RGD:1306247
See related: EnsemblRapid:ENSRNOG00000016630 AllianceGenome:RGD:1306247
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tln
Summary: Enables integrin binding activity. Predicted to be involved in several processes, including integrin activation; integrin-mediated signaling pathway; and platelet aggregation. Predicted to act upstream of or within cell-substrate junction assembly and cortical actin cytoskeleton organization. Predicted to be located in adherens junction. Predicted to be active in cytoplasm; focal adhesion; and plasma membrane. Orthologous to human TLN1 (talin 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 810.5), Lung (RPKM 605.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q22

Exon count:: 58

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (62583730..62613687, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (57787670..57817900, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (59033635..59063592, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study found that overexpression of the talin head activated axonal integrins but inhibited downstream signaling via FAK, and did not promote axon growth.
Title: Full length talin stimulates integrin activation and axon regeneration.
Talin and paxillin showed a major distributional change between different hormone regimes, estrogen and progesterone
Title: Ovarian hormones regulate expression of the focal adhesion proteins, talin and paxillin, in rat uterine luminal but not glandular epithelial cells.
Uterine epithelial cells are less adherent to the underlying basal lamina due to the disassembly of talin and paxillin from focal adhesions, facilitating removal of these cells at the time of implantation.
Title: Focal adhesions disassemble during early pregnancy in rat uterine epithelial cells.
Talin during muscle development is phosphorylated and localizes to cell membrane.
Title: Talin distribution during the differentiation of satellite cells isolated from rat skeletal muscle.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH130044 (e-PCR)
- UniSTS:213332

RH140058 (e-PCR)
- UniSTS:222139

PMC114562P4 (e-PCR)
- UniSTS:270272

MARC_9998-9999:997196716:1 (e-PCR)
- UniSTS:270046

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables LIM domain binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	IPI Inferred from Physical Interaction more info	PubMed
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylserine binding	ISO Inferred from Sequence Orthology more info
enables structural constituent of cytoskeleton	IEA Inferred from Electronic Annotation more info
enables vinculin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in biological_process	ND No biological Data available more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell-substrate junction assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cortical actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in cortical microtubule organization	IEA Inferred from Electronic Annotation more info
involved_in cortical microtubule organization	ISO Inferred from Sequence Orthology more info
involved_in integrin activation	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in platelet aggregation	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
located_in adherens junction	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in ruffle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: talin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039025.2 → NP_001034114.2 talin-1

See identical proteins and their annotated locations for NP_001034114.2

Status: PROVISIONAL

Source sequence(s)

CH473962

UniProtKB/TrEMBL

A6IJ31, A6IJ32, G3V852

Related

ENSRNOP00000022401.6, ENSRNOT00000022400.7

Conserved Domains (10) summary

cd12150
Location:1654 → 1826

talin-RS; rod-segment of the talin C-terminal domain

smart00295
Location:88 → 313

B41; Band 4.1 homologues

smart00307
Location:2336 → 2532

ILWEQ; I/LWEQ domain

cd10569
Location:309 → 400

FERM_C_Talin; FERM domain C-lobe/F3 of Talin

pfam00373
Location:204 → 313

FERM_M; FERM central domain

pfam08913
Location:1849 → 1973

VBS; Vinculin Binding Site

pfam09141
Location:491 → 652

Talin_middle; Talin, middle domain

pfam09379
Location:90 → 186

FERM_N; FERM N-terminal domain

pfam16511
Location:4 → 83

FERM_f0; N-terminal or F0 domain of Talin-head FERM

cl19756
Location:822 → 912

I_LWEQ; I/LWEQ domain