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    Dcaf5 DDB1 and CUL4 associated factor 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314273, updated on 9-Dec-2024

    Summary

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    Symbol
    Dcaf5provided by RGD
    Full Name
    DDB1 and CUL4 associated factor 5provided by RGD
    Primary source
    RGD:1306535
    See related
    EnsemblRapid:ENSRNOG00000004556 AllianceGenome:RGD:1306535
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Wdr22
    Summary
    Predicted to be involved in negative regulation of fatty acid biosynthetic process. Predicted to be located in nucleus. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human DCAF5 (DDB1 and CUL4 associated factor 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 127.2), Muscle (RPKM 121.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dcaf5 in Genome Data Viewer
    Location:
    6q24
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (104904423..104993150, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (99171506..99260183, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (103516586..103605288, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120103564 Neighboring gene actinin, alpha 1 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 2, pseudogene 1 Neighboring gene small Cajal body-specific RNA 3 Neighboring gene uncharacterized LOC120103565 Neighboring gene macrophage migration inhibitory factor like 3 Neighboring gene TATA-box binding protein associated factor 8 like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. Jin J, et al. Mol Cell, 2006 Sep 1. PMID 16949367
    2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in negative regulation of fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul4-RING E3 ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Cul4-RING E3 ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DDB1- and CUL4-associated factor 5
    Names
    DDB1- and CUL4-associated factor 5-like
    WD repeat domain 22
    breakpoint cluster region protein, uterine leiomyoma, 2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100718.1 → NP_001094188.1  DDB1- and CUL4-associated factor 5

      See identical proteins and their annotated locations for NP_001094188.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6AVX6, A6HCI8, G3V6K4
      Related
      ENSRNOP00000006005.6, ENSRNOT00000006005.8
      Conserved Domains (2) summary
      sd00039
      Location:57 → 98
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:49 → 361
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      104904423..104993150 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008764782.4 → XP_008763004.1  DDB1- and CUL4-associated factor 5 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AVX6
      Conserved Domains (3) summary
      COG2319
      Location:15 → 308
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:51 → 87
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:19 → 308
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_006240279.5 → XP_006240341.1  DDB1- and CUL4-associated factor 5 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AVX6
      Related
      ENSRNOP00000097052.1, ENSRNOT00000094678.2
      Conserved Domains (3) summary
      COG2319
      Location:18 → 284
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:22 → 58
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:13 → 317
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. XM_017594145.3 → XP_017449634.1  DDB1- and CUL4-associated factor 5 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AVX6
      Conserved Domains (3) summary
      COG2319
      Location:18 → 284
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:22 → 58
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:13 → 317
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein Strain
    Heading Accession and Version

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