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    Zdhhc8 zinc finger DHHC-type palmitoyltransferase 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303796, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zdhhc8provided by RGD
    Official Full Name
    zinc finger DHHC-type palmitoyltransferase 8provided by RGD
    Primary source
    RGD:1308875
    See related
    EnsemblRapid:ENSRNOG00000021891 AllianceGenome:RGD:1308875
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable palmitoyltransferase activity. Predicted to be involved in peptidyl-L-cysteine S-palmitoylation; positive regulation of cholesterol efflux; and regulation of postsynapse assembly. Predicted to act upstream of or within locomotory behavior. Predicted to be located in mitochondrion. Predicted to be active in Golgi apparatus; glutamatergic synapse; and postsynapse. Orthologous to human ZDHHC8 (zinc finger DHHC-type palmitoyltransferase 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 30.3), Heart (RPKM 23.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zdhhc8 in Genome Data Viewer
    Location:
    11q23
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (96259383..96273588)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (82755110..82769280)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (86903122..86917261)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene tRNA methyltransferase 2 homolog A Neighboring gene RAN binding protein 1 Neighboring gene small nucleolar RNA, H/ACA box 77B Neighboring gene coiled-coil domain containing 188 Neighboring gene uncharacterized LOC102555338

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Evidence that the gene encoding ZDHHC8 contributes to the risk of schizophrenia. Mukai J, et al. Nat Genet, 2004 Jul. PMID 15184899
    2. Palmitoylation by DHHC5/8 targets GRIP1 to dendritic endosomes to regulate AMPA-R trafficking. Thomas GM, et al. Neuron, 2012 Feb 9. PMID 22325201, Free PMC Article
    3. Mitochondrial localization and function of a subset of 22q11 deletion syndrome candidate genes. Maynard TM, et al. Mol Cell Neurosci, 2008 Nov. PMID 18775783, Free PMC Article
    4. Analysis of substrate specificity of human DHHC protein acyltransferases using a yeast expression system. Ohno Y, et al. Mol Biol Cell, 2012 Dec. PMID 23034182, Free PMC Article
    5. Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy. Ivatt RM, et al. Proc Natl Acad Sci U S A, 2014 Jun 10. PMID 24912190, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables palmitoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-L-cysteine S-palmitoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation by host of viral process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cholesterol efflux IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cholesterol efflux ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein palmitoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of postsynapse assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    palmitoyltransferase ZDHHC8
    Names
    probable palmitoyltransferase ZDHHC8
    zinc finger, DHHC domain containing 8
    zinc finger, DHHC-type containing 8
    zinc finger, DHHC-type containing 8-like
    NP_001034110.1
    XP_006248672.1
    XP_038944196.1
    XP_038944197.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039021.3 → NP_001034110.1  palmitoyltransferase ZDHHC8

      See identical proteins and their annotated locations for NP_001034110.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A0A8I6A4S3, Q2THW6
      Related
      ENSRNOP00000040329.2, ENSRNOT00000048063.5
      Conserved Domains (1) summary
      pfam01529
      Location:99 → 224
      zf-DHHC; DHHC palmitoyltransferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      96259383..96273588
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039088268.2 → XP_038944196.1  palmitoyltransferase ZDHHC8 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A4S3

    2. XM_006248610.5 → XP_006248672.1  palmitoyltransferase ZDHHC8 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A4S3
      Related
      ENSRNOP00000101586.1, ENSRNOT00000132141.1
      Conserved Domains (1) summary
      pfam01529
      Location:99 → 224
      zf-DHHC; DHHC palmitoyltransferase

    3. XM_039088269.2 → XP_038944197.1  palmitoyltransferase ZDHHC8 isoform X3

      UniProtKB/TrEMBL
      A6JSI2
    Nucleotide Protein Strain
    Heading Accession and Version

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