Abhd6 abhydrolase domain containing 6, acylglycerol lipase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Abhd6provided by RGD
Official Full Name: abhydrolase domain containing 6, acylglycerol lipaseprovided by RGD
Primary source: RGD:1359323
See related: EnsemblRapid:ENSRNOG00000008167 AllianceGenome:RGD:1359323
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable monoacylglycerol lipase activity and phospholipase activity. Predicted to be involved in several processes, including glycerolipid metabolic process; negative regulation of cold-induced thermogenesis; and regulation of retrograde trans-synaptic signaling by endocanabinoid. Predicted to act upstream of or within long-term synaptic depression; negative regulation of cell migration; and regulation of endocannabinoid signaling pathway. Predicted to be located in late endosome membrane; lysosomal membrane; and mitochondrion. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic membrane. Orthologous to human ABHD6 (abhydrolase domain containing 6, acylglycerol lipase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 156.6), Kidney (RPKM 89.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p14

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (19289967..19337500, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (16859740..16907094, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (18647903..18695133, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypic Characterization of the Endocannabinoid-Degrading Enzyme Alpha/Beta-Hydrolase Domain 6 Knockout Rat.
Title: Phenotypic Characterization of the Endocannabinoid-Degrading Enzyme Alpha/Beta-Hydrolase Domain 6 Knockout Rat.

Submit: New GeneRIF Correction

General gene information

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Markers

D15Rat138 (e-PCR), detects polymorphism
- UniSTS:226698

RH128805 (e-PCR)
- UniSTS:212113

AV065425 (e-PCR)
- UniSTS:164545

RH124456 (e-PCR)
- UniSTS:161278

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables monoacylglycerol lipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables monoacylglycerol lipase activity	ISO Inferred from Sequence Orthology more info
enables monoacylglycerol lipase activity	ISS Inferred from Sequence or Structural Similarity more info
enables phospholipase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in acylglycerol catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in acylglycerol catabolic process	ISO Inferred from Sequence Orthology more info
involved_in acylglycerol catabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within long-term synaptic depression	ISO Inferred from Sequence Orthology more info
involved_in lysobisphosphatidic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in lysobisphosphatidic acid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in monoacylglycerol catabolic process	ISO Inferred from Sequence Orthology more info
involved_in monoacylglycerol catabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in phospholipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lipid biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of endocannabinoid signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of retrograde trans-synaptic signaling by endocanabinoid	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of AMPA glutamate receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of AMPA glutamate receptor complex	ISO Inferred from Sequence Orthology more info
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in late endosome membrane	ISO Inferred from Sequence Orthology more info
located_in late endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: monoacylglycerol lipase ABHD6

Names: 2-arachidonoylglycerol hydrolase; abhydrolase domain-containing protein 6

NP_001007681.1

EC 3.1.1.23

XP_006251829.1

EC 3.1.1.23

XP_038949180.1

EC 3.1.1.23

XP_063130269.1

EC 3.1.1.23

XP_063130271.1

EC 3.1.1.23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007680.1 → NP_001007681.1 monoacylglycerol lipase ABHD6

See identical proteins and their annotated locations for NP_001007681.1

Status: PROVISIONAL

Source sequence(s)

BC083826

UniProtKB/Swiss-Prot

Q5XI64

UniProtKB/TrEMBL

A0A8L2R9X1, A6K0C2

Related

ENSRNOP00000012271.3, ENSRNOT00000012271.6

Conserved Domains (1) summary

COG0596
Location:51 → 327

MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

19289967..19337500 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006251767.5 → XP_006251829.1 monoacylglycerol lipase ABHD6 isoform X1

See identical proteins and their annotated locations for XP_006251829.1

UniProtKB/Swiss-Prot

Q5XI64

UniProtKB/TrEMBL

A0A8L2R9X1, A6K0C2

Conserved Domains (1) summary

COG0596
Location:51 → 327

MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
XM_063274199.1 → XP_063130269.1 monoacylglycerol lipase ABHD6 isoform X2

UniProtKB/TrEMBL

A0A8L2R9X1

Related

ENSRNOP00000074573.3, ENSRNOT00000080794.3
XM_039093252.2 → XP_038949180.1 monoacylglycerol lipase ABHD6 isoform X4

Conserved Domains (1) summary

PRK14875
Location:1 → 179

PRK14875; acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional
XM_063274201.1 → XP_063130271.1 monoacylglycerol lipase ABHD6 isoform X3