Adamts15 ADAM metallopeptidase with thrombospondin type 1 motif, 15 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adamts15provided by RGD
Official Full Name: ADAM metallopeptidase with thrombospondin type 1 motif, 15provided by RGD
Primary source: RGD:1309770
See related: EnsemblRapid:ENSRNOG00000009892 AllianceGenome:RGD:1309770
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable extracellular matrix binding activity; heparin binding activity; and metalloendopeptidase activity. Predicted to be involved in extracellular matrix disassembly; myoblast fusion; and proteolysis. Predicted to be located in cell surface and extracellular space. Predicted to be active in extracellular matrix. Human ortholog(s) of this gene implicated in distal arthrogryposis. Orthologous to human ADAMTS15 (ADAM metallopeptidase with thrombospondin type 1 motif 15). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 109.6), Heart (RPKM 41.3) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q13

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (37566064..37589446, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (29307864..29331249, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (31977001..32000378, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables extracellular matrix binding	ISO Inferred from Sequence Orthology more info
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in extracellular matrix disassembly	ISO Inferred from Sequence Orthology more info
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in myoblast fusion	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in collagen-containing extracellular matrix	IEA Inferred from Electronic Annotation more info
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: A disintegrin and metalloproteinase with thrombospondin motifs 15

Names: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106810.1 → NP_001100280.1 A disintegrin and metalloproteinase with thrombospondin motifs 15 precursor

See identical proteins and their annotated locations for NP_001100280.1

Status: PROVISIONAL

Source sequence(s)

CH474007

UniProtKB/TrEMBL

A6JYF3, D3ZXM1

Related

ENSRNOP00000013341.5, ENSRNOT00000013341.7

Conserved Domains (6) summary

smart00209
Location:519 → 571

TSP1; Thrombospondin type 1 repeats

cd04273
Location:218 → 424

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01421
Location:218 → 427

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:42 → 157

Pep_M12B_propep; Reprolysin family propeptide

pfam05986
Location:683 → 801

ADAM_spacer1; ADAM-TS Spacer 1

cl15456
Location:437 → 506

ADAM_CR; ADAM cysteine-rich

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

37566064..37589446 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039081021.2 → XP_038936949.1 A disintegrin and metalloproteinase with thrombospondin motifs 15 isoform X1

Conserved Domains (5) summary

smart00209
Location:188 → 240

TSP1; Thrombospondin type 1 repeats

pfam05986
Location:352 → 470

ADAM_spacer1; ADAM-TS Spacer 1

pfam17771
Location:107 → 174

ADAM_CR_2; ADAM cysteine-rich domain

pfam19030
Location:566 → 619

TSP1_ADAMTS; Thrombospondin type 1 domain

cl00064
Location:1 → 93

ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
XM_039081020.1 → XP_038936948.1 A disintegrin and metalloproteinase with thrombospondin motifs 15 isoform X1

Conserved Domains (5) summary

smart00209
Location:188 → 240

TSP1; Thrombospondin type 1 repeats

pfam05986
Location:352 → 470

ADAM_spacer1; ADAM-TS Spacer 1

pfam17771
Location:107 → 174

ADAM_CR_2; ADAM cysteine-rich domain

pfam19030
Location:566 → 619

TSP1_ADAMTS; Thrombospondin type 1 domain

cl00064
Location:1 → 93

ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
XM_039081019.1 → XP_038936947.1 A disintegrin and metalloproteinase with thrombospondin motifs 15 isoform X1

Conserved Domains (5) summary

smart00209
Location:188 → 240

TSP1; Thrombospondin type 1 repeats

pfam05986
Location:352 → 470

ADAM_spacer1; ADAM-TS Spacer 1

pfam17771
Location:107 → 174

ADAM_CR_2; ADAM cysteine-rich domain

pfam19030
Location:566 → 619

TSP1_ADAMTS; Thrombospondin type 1 domain

cl00064
Location:1 → 93

ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
XM_039081022.2 → XP_038936950.1 A disintegrin and metalloproteinase with thrombospondin motifs 15 isoform X1

Conserved Domains (5) summary

smart00209
Location:188 → 240

TSP1; Thrombospondin type 1 repeats

pfam05986
Location:352 → 470

ADAM_spacer1; ADAM-TS Spacer 1

pfam17771
Location:107 → 174

ADAM_CR_2; ADAM cysteine-rich domain

pfam19030
Location:566 → 619

TSP1_ADAMTS; Thrombospondin type 1 domain

cl00064
Location:1 → 93

ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...