Dnaaf5 dynein, axonemal, assembly factor 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dnaaf5provided by RGD
Official Full Name: dynein, axonemal, assembly factor 5provided by RGD
Primary source: RGD:1566028
See related: EnsemblRapid:ENSRNOG00000021312 AllianceGenome:RGD:1566028
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Heatr2
Summary: Predicted to enable dynein intermediate chain binding activity. Predicted to be involved in cilium movement; inner dynein arm assembly; and outer dynein arm assembly. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 18. Orthologous to human DNAAF5 (dynein axonemal assembly factor 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 66.7), Kidney (RPKM 41.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q11

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (20567482..20606600, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (15453636..15492722, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (17545468..17584466, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables dynein intermediate chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein intermediate chain binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cilium movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in cilium movement	ISO Inferred from Sequence Orthology more info
involved_in inner dynein arm assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in inner dynein arm assembly	ISO Inferred from Sequence Orthology more info
involved_in outer dynein arm assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in outer dynein arm assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
NOT located_in motile cilium	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dynein axonemal assembly factor 5

Names: HEAT repeat containing 2; HEAT repeat-containing protein 2; dynein assembly factor 5, axonemal

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001134857.1 → NP_001128329.1 dynein axonemal assembly factor 5

See identical proteins and their annotated locations for NP_001128329.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000012

UniProtKB/TrEMBL

A6K1X9, G3V943

Related

ENSRNOP00000098695.1, ENSRNOT00000164513.1

Conserved Domains (2) summary

pfam13830
Location:39 → 196

DUF4192; Domain of unknown function (DUF4192)

sd00044
Location:698 → 726

HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

20567482..20606600 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039089394.2 → XP_038945322.1 dynein axonemal assembly factor 5 isoform X1

Conserved Domains (2) summary

sd00044
Location:555 → 583

HEAT; HEAT repeat [structural motif]

NF033442
Location:136 → 208

BREX_PglW; BREX system serine/threonine kinase PglW

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001034141.1: Suppressed sequence

Description

NM_001034141.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.