Iffo2 intermediate filament family orphan 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Iffo2provided by RGD
Official Full Name: intermediate filament family orphan 2provided by RGD
Primary source: RGD:1624207
See related: EnsemblRapid:ENSRNOG00000071266 AllianceGenome:RGD:1624207
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable 1-pyrroline-5-carboxylate dehydrogenase activity. Predicted to be involved in proline catabolic process to glutamate. Predicted to be located in intermediate filament; membrane; and mitochondrial matrix. Orthologous to human IFFO2 (intermediate filament family orphan 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 64.1), Kidney (RPKM 53.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (157114089..157160135)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (151830900..151876948)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (158042587..158083311)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 1-pyrroline-5-carboxylate dehydrogenase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in proline catabolic process to glutamate	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in intermediate filament	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: intermediate filament family orphan 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001134703.2 → NP_001128175.2 intermediate filament family orphan 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A0A8L2R1U3

Related

ENSRNOP00000098376.2, ENSRNOT00000120750.2

Conserved Domains (1) summary

pfam00038
Location:189 → 478

Filament; Intermediate filament protein