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    Zfp438 zinc finger protein 438 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307024, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp438provided by RGD
    Official Full Name
    zinc finger protein 438provided by RGD
    Primary source
    RGD:1307214
    See related
    EnsemblRapid:ENSRNOG00000028329 AllianceGenome:RGD:1307214
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307214
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Predicted to be involved in negative regulation of DNA-templated transcription and regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Orthologous to human ZNF438 (zinc finger protein 438). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 33.3), Testes (RPKM 29.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfp438 in Genome Data Viewer
    Location:
    17q12.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (57121637..57242892)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (52426221..52547472)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (55006893..55131567)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene translation initiation factor IF-2-like Neighboring gene uncharacterized LOC134482725 Neighboring gene uncharacterized LOC108348574 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene heat shock protein family A (Hsp70) member 8, pseudogene 1 Neighboring gene NADH:ubiquinone oxidoreductase subunit B3 like 3 Neighboring gene uncharacterized LOC108348573 Neighboring gene supervillin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of a novel human zinc finger gene, ZNF438, with transcription inhibition activity. Zhong Z, et al. J Biochem Mol Biol, 2007 Jul 31. PMID 17669267
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 438

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107358.1 → NP_001100828.1  zinc finger protein 438

      See identical proteins and their annotated locations for NP_001100828.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474030
      UniProtKB/TrEMBL
      A0A8I5ZQC0, A6K9F0, D4ACS2
      Conserved Domains (3) summary
      PHA03269
      Location:88 → 236
      PHA03269; envelope glycoprotein C; Provisional
      sd00017
      Location:494 → 514
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:520 → 542
      zf-C2H2; Zinc finger, C2H2 type

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      57121637..57242892
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276461.1 → XP_063132531.1  zinc finger protein 438 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZQC0, A6K9F0, D4ACS2

    2. XM_039095727.2 → XP_038951655.1  zinc finger protein 438 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZQC0, A6K9F0, D4ACS2
      Related
      ENSRNOP00000033287.4, ENSRNOT00000033827.7
      Conserved Domains (3) summary
      PHA03269
      Location:88 → 236
      PHA03269; envelope glycoprotein C; Provisional
      sd00017
      Location:494 → 514
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:520 → 542
      zf-C2H2; Zinc finger, C2H2 type

    3. XM_017600559.3 → XP_017456048.1  zinc finger protein 438 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZQC0, A6K9F0, D4ACS2
      Conserved Domains (3) summary
      PHA03269
      Location:88 → 236
      PHA03269; envelope glycoprotein C; Provisional
      sd00017
      Location:494 → 514
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:520 → 542
      zf-C2H2; Zinc finger, C2H2 type

    4. XM_017600557.3 → XP_017456046.1  zinc finger protein 438 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JU08, A0A8I6AA68
      Related
      ENSRNOP00000068915.1, ENSRNOT00000086342.3
      Conserved Domains (2) summary
      sd00017
      Location:497 → 517
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:509 → 534
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

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