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    Dkk3 dickkopf WNT signaling pathway inhibitor 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171548, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dkk3provided by RGD
    Official Full Name
    dickkopf WNT signaling pathway inhibitor 3provided by RGD
    Primary source
    RGD:621846
    See related
    EnsemblRapid:ENSRNOG00000016343 AllianceGenome:RGD:621846
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    p29; Reic
    Summary
    Predicted to enable co-receptor binding activity and receptor antagonist activity. Predicted to be involved in several processes, including adrenal gland development; negative regulation of canonical Wnt signaling pathway; and negative regulation of steroid hormone biosynthetic process. Predicted to be active in extracellular space. Orthologous to human DKK3 (dickkopf WNT signaling pathway inhibitor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 377.4), Brain (RPKM 198.2) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dkk3 in Genome Data Viewer
    Location:
    1q33
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (175672834..175715867, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (166237969..166281271, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (176940424..176983076, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene ubiquitin specific peptidase 47 Neighboring gene microtubule associated monooxygenase, calponin and LIM domain containing 2 Neighboring gene parvin, alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. DKK3 ameliorates neuropathic pain via inhibiting ASK-1/JNK/p-38-mediated microglia polarization and neuroinflammation. Zhang LQ, et al. J Neuroinflammation, 2022 Jun 3. PMID 35658977, Free PMC Article
    2. Dickkopf-related protein 3 negatively regulates the osteogenic differentiation of rat dental follicle cells. Zhang X, et al. Mol Med Rep, 2017 Apr. PMID 28259940, Free PMC Article
    3. Cloning, expression, and functional characterization of the substrate binding subunit of rat type II iodothyronine 5'-deiodinase. Leonard DM, et al. J Biol Chem, 2000 Aug 18. PMID 10829019
    4. Role of Dickkopf-3 in Blood Pressure Regulation in Mice and Hypertensive Rats. Busceti CL, et al. Circ Res, 2023 May 26. PMID 37144413
    5. Divergent expression of type 2 deiodinase and the putative thyroxine-binding protein p29, in rat brain, suggests that they are functionally unrelated proteins. Montero-Pedrazuela A, et al. Endocrinology, 2003 Mar. PMID 12586781

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Role of Dickkopf-3 in Blood Pressure Regulation in Mice and Hypertensive Rats.
      Title: Role of Dickkopf-3 in Blood Pressure Regulation in Mice and Hypertensive Rats.
    2. DKK3 ameliorates neuropathic pain via inhibiting ASK-1/JNK/p-38-mediated microglia polarization and neuroinflammation.
      Title: DKK3 ameliorates neuropathic pain via inhibiting ASK-1/JNK/p-38-mediated microglia polarization and neuroinflammation.
    3. DKK3 expression negatively regulates the osteogenic differentiation of dental follicle cells.
      Title: Dickkopf-related protein 3 negatively regulates the osteogenic differentiation of rat dental follicle cells.
    4. WNT7A can specifically act via a Frizzled-5.LRP6 receptor complex in PC12 cells and that this activity can be antagonized by Dickkopf-1 and Dickkopf-3.
      Title: Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins.
    5. data do not support that thyroxine-binding protein p29 has a functional relationship with D2, but expression of p29 in the blood-CSF barrier suggests that it might be involved in T(4) transport to and from the CSF
      Title: Divergent expression of type 2 deiodinase and the putative thyroxine-binding protein p29, in rat brain, suggests that they are functionally unrelated proteins.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables co-receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables receptor antagonist activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adrenal gland development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of aldosterone biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cortisol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dickkopf-related protein 3
    Names
    dickkopf 3 homolog
    dickkopf homolog 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138519.2 → NP_612528.2  dickkopf-related protein 3 precursor

      See identical proteins and their annotated locations for NP_612528.2

      Status: VALIDATED

      Source sequence(s)
      BC160821, JAXUCZ010000001
      UniProtKB/TrEMBL
      A6I857, B1H219, F7F7Y6
      Related
      ENSRNOP00000022301.5, ENSRNOT00000022301.8
      Conserved Domains (2) summary
      pfam06607
      Location:208 → 273
      Prokineticin; Prokineticin
      pfam04706
      Location:147 → 196
      Dickkopf_N; Dickkopf N-terminal cysteine-rich region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      175672834..175715867 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006230009.5 → XP_006230071.1  dickkopf-related protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006230071.1

      UniProtKB/TrEMBL
      A6I857, B1H219, F7F7Y6
      Conserved Domains (2) summary
      pfam06607
      Location:208 → 273
      Prokineticin; Prokineticin
      pfam04706
      Location:147 → 196
      Dickkopf_N; Dickkopf N-terminal cysteine-rich region

    2. XM_017588739.3 → XP_017444228.1  dickkopf-related protein 3 isoform X1

      UniProtKB/TrEMBL
      A6I857, B1H219, F7F7Y6
      Conserved Domains (2) summary
      pfam06607
      Location:208 → 273
      Prokineticin; Prokineticin
      pfam04706
      Location:147 → 196
      Dickkopf_N; Dickkopf N-terminal cysteine-rich region
    Nucleotide Protein Strain
    Heading Accession and Version

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