Kcnk3 potassium two pore domain channel subfamily K member 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kcnk3provided by RGD
Official Full Name: potassium two pore domain channel subfamily K member 3provided by RGD
Primary source: RGD:61997
See related: EnsemblRapid:ENSRNOG00000009790 AllianceGenome:RGD:61997
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: rTASK; Task-1
Summary: Enables open rectifier potassium channel activity. Involved in several processes, including cellular response to zinc ion; positive regulation of voltage-gated potassium channel activity; and regulation of resting membrane potential. Predicted to be located in membrane. Predicted to be active in plasma membrane. Used to study pulmonary hypertension and pulmonary venoocclusive disease. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in primary pulmonary hypertension. Orthologous to human KCNK3 (potassium two pore domain channel subfamily K member 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 258.0), Heart (RPKM 66.2) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q14

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (31483129..31519061, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (25761487..25799153, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (27154274..27190209, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Exploring the involvement of TASK-1 in the control of isolated rat right atrium function from healthy animals and an experimental model of monocrotaline-induced pulmonary hypertension.
Title: Exploring the involvement of TASK-1 in the control of isolated rat right atrium function from healthy animals and an experimental model of monocrotaline-induced pulmonary hypertension.
Kcnk3 dysfunction exaggerates the development of pulmonary hypertension induced by left ventricular pressure overload.
Title: Kcnk3 dysfunction exaggerates the development of pulmonary hypertension induced by left ventricular pressure overload.
TASK-1 regulates mitochondrial function under hypoxia.
Title: TASK-1 regulates mitochondrial function under hypoxia.
Restoration of Vitamin D Levels Improves Endothelial Function and Increases TASK-Like K(+) Currents in Pulmonary Arterial Hypertension Associated with Vitamin D Deficiency.
Title: Restoration of Vitamin D Levels Improves Endothelial Function and Increases TASK-Like K(+) Currents in Pulmonary Arterial Hypertension Associated with Vitamin D Deficiency.
TASK-1 channel blockade by AVE1231 increases vasocontractile responses and BP in 1- to 2-week-old but not adult rats.
Title: TASK-1 channel blockade by AVE1231 increases vasocontractile responses and BP in 1- to 2-week-old but not adult rats.
Down-regulation of lncRNA Gas5 promotes hypoxia-induced pulmonary arterial smooth muscle cell proliferation by regulating KCNK3 expression.
Title: Down-regulation of lncRNA Gas5 promotes hypoxia-induced pulmonary arterial smooth muscle cell proliferation by regulating KCNK3 expression.
Expression of p11 and Heteromeric TASK Channels in Rat Carotid Body Glomus Cells and Nerve Growth Factor-differentiated PC12 Cells.
Title: Expression of p11 and Heteromeric TASK Channels in Rat Carotid Body Glomus Cells and Nerve Growth Factor-differentiated PC12 Cells.
Muscarinic receptor stimulation induces TASK1 channel endocytosis through a PKC-Pyk2-Src pathway in PC12 cells.
Title: Muscarinic receptor stimulation induces TASK1 channel endocytosis through a PKC-Pyk2-Src pathway in PC12 cells.
Vitamin D deficiency downregulates TASK-1 channels and induces pulmonary vascular dysfunction.
Title: Vitamin D deficiency downregulates TASK-1 channels and induces pulmonary vascular dysfunction.
The first Kcnk3-mutated rat model of pulmonary hypertension is established. KCNK3 loss of function is a key event in pulmonary arterial hypertension pathogenesis.
Title: Characterization of Kcnk3-Mutated Rat, a Novel Model of Pulmonary Hypertension.

Submit: New GeneRIF Correction See all GeneRIFs (45)

General gene information

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Markers

Kcnk3 (e-PCR), detects polymorphism
- UniSTS:547595

D6Wox33 (e-PCR)
- UniSTS:518923

Kcnk3 (e-PCR), detects polymorphism
- UniSTS:547596

PMC16288P1 (e-PCR)
- UniSTS:271473

PMC16288P2 (e-PCR)
- UniSTS:271474

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables S100 protein binding	ISO Inferred from Sequence Orthology more info
enables monoatomic ion channel activity	ISO Inferred from Sequence Orthology more info
enables open rectifier potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables open rectifier potassium channel activity	IEA Inferred from Electronic Annotation more info
enables outward rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables outward rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
enables outward rectifier potassium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables potassium ion leak channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium ion leak channel activity	ISO Inferred from Sequence Orthology more info
enables potassium ion leak channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables sodium channel activity	IEA Inferred from Electronic Annotation more info
enables sodium channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to acidic pH	IEA Inferred from Electronic Annotation more info
involved_in cellular response to acidic pH	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to zinc ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in cochlea development	IEP Inferred from Expression Pattern more info	PubMed
involved_in detection of hypoxic conditions in blood by carotid body chemoreceptor signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in monoatomic ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of voltage-gated potassium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of action potential firing rate	IEA Inferred from Electronic Annotation more info
involved_in regulation of resting membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: potassium channel subfamily K member 3

Names: TWIK-related acid-sensitive K(+) channel 1; TWIK-related acid-sensitive K+ channel; acid-sensitive potassium channel protein TASK-1; potassium channel, subfamily K, member 3; potassium channel, two pore domain subfamily K, member 3; two pore K(+) channel KT3.1; two pore potassium channel KT3.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.