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    Fsd1 fibronectin type III and SPRY domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301506, updated on 9-Dec-2024

    Summary

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    Symbol
    Fsd1provided by RGD
    Full Name
    fibronectin type III and SPRY domain containing 1provided by RGD
    Primary source
    RGD:1583850
    See related
    AllianceGenome:RGD:1583850
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fsd1l1
    Summary
    Predicted to enable identical protein binding activity and microtubule binding activity. Predicted to be involved in cytoplasmic microtubule organization; regulation of cytokinesis; and regulation of mitotic spindle organization. Predicted to be located in centrosome and microtubule. Orthologous to human FSD1 (fibronectin type III and SPRY domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 91.7), Adrenal (RPKM 25.8) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fsd1 in Genome Data Viewer
    Location:
    9q11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (905418..908938)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (818241..821761)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (11076670..11080190, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480467 Neighboring gene YJU2 splicing factor Neighboring gene src homology 2 domain-containing transforming protein D Neighboring gene signal transducing adaptor family member 2 Neighboring gene MPN domain containing Neighboring gene SH3 domain containing GRB2 like 1, endophilin A2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of a novel microtubule-associated protein that regulates microtubule organization and cytokinesis by using a GFP-screening strategy. Manabe Ri, et al. Curr Biol, 2002 Nov 19. PMID 12445389
    2. A novel centrosome-associated protein with affinity for microtubules. Stein PA, et al. J Cell Sci, 2002 Sep 1. PMID 12154070
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoplasmic microtubule organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitotic spindle organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cleavage furrow IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    fibronectin type III and SPRY domain-containing protein 1
    Names
    fibronectin type 3 and SPRY domain-containing protein
    fibronectin type 3 and SPRY domain-containing protein-like1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106918.1 → NP_001100388.1  fibronectin type III and SPRY domain-containing protein 1

      See identical proteins and their annotated locations for NP_001100388.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474092
      UniProtKB/TrEMBL
      A6KR21
      Conserved Domains (1) summary
      cl23765
      Location:4 → 120
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      905418..908938
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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