U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Batf3 basic leucine zipper ATF-like transcription factor 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 60462, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Batf3provided by RGD
    Official Full Name
    basic leucine zipper ATF-like transcription factor 3provided by RGD
    Primary source
    RGD:620501
    See related
    AllianceGenome:RGD:620501
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Jdp1
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in myeloid dendritic cell differentiation; negative regulation of transcription by RNA polymerase II; and response to virus. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Orthologous to human BATF3 (basic leucine zipper ATF-like transcription factor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 54.5), Thymus (RPKM 30.7) and 8 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Batf3 in Genome Data Viewer
    Location:
    13q27
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (105220782..105232365)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (102689657..102701241)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (109713376..109726438)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene TatD DNase domain containing 3 Neighboring gene NSL1 component of MIS12 kinetochore complex Neighboring gene uncharacterized LOC120096350 Neighboring gene golgi associated RAB2 interactor family member 4 Neighboring gene activating transcription factor 3 Neighboring gene uncharacterized LOC102555043 Neighboring gene uncharacterized LOC102555129

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity. Hildner K, et al. Science, 2008 Nov 14. PMID 19008445, Free PMC Article
    2. Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8alpha+ conventional dendritic cells. Edelson BT, et al. J Exp Med, 2010 Apr 12. PMID 20351058, Free PMC Article
    3. Transcriptional repression of MMP-1 by p21SNFT and reduced in vitro invasiveness of hepatocarcinoma cells. Bower KE, et al. Oncogene, 2004 Nov 18. PMID 15467742
    4. Repression of IL-2 promoter activity by the novel basic leucine zipper p21SNFT protein. Iacobelli M, et al. J Immunol, 2000 Jul 15. PMID 10878360
    5. Characterization of JDP genes, an evolutionarily conserved J domain-only protein family, from human and moths. Lee J, et al. Biochim Biophys Acta, 2000 Apr 25. PMID 10760603

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in dendritic cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dendritic cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within myeloid dendritic cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in myeloid dendritic cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in myeloid dendritic cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to virus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of RNA polymerase II transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    basic leucine zipper transcriptional factor ATF-like 3
    Names
    B-ATF-3
    JDP-1
    Jun dimerization protein 1
    basic leucine zipper transcription factor, ATF-like 3

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021865.2 → NP_068637.2  basic leucine zipper transcriptional factor ATF-like 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/Swiss-Prot
      P97876
      UniProtKB/TrEMBL
      A6JGY7
      Conserved Domains (2) summary
      cd14686
      Location:30 → 84
      bZIP; coiled coil [structural motif]
      cl21462
      Location:28 → 85
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      105220782..105232365
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97876.1 GenPept UniProtKB/Swiss-Prot:P97876

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools