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    Coq8a coenzyme Q8A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360887, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Coq8aprovided by RGD
    Official Full Name
    coenzyme Q8Aprovided by RGD
    Primary source
    RGD:1308245
    See related
    EnsemblRapid:ENSRNOG00000043201 AllianceGenome:RGD:1308245
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Adck3; Cabc1
    Summary
    Predicted to enable ADP binding activity and kinase activity. Predicted to be involved in phosphorylation and ubiquinone biosynthetic process. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 4. Orthologous to human COQ8A (coenzyme Q8A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 2146.4), Liver (RPKM 1093.1) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Coq8a in Genome Data Viewer
    Location:
    13q26
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (94436680..94465535, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (91904731..91933588, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (98451629..98480438, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481630 Neighboring gene CDC42 binding protein kinase alpha Neighboring gene uncharacterized LOC102553289 Neighboring gene presenilin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nonsense mutations in CABC1/ADCK3 cause progressive cerebellar ataxia and atrophy. Gerards M, et al. Mitochondrion, 2010 Aug. PMID 20580948
    2. Mitochondrial ADCK3 employs an atypical protein kinase-like fold to enable coenzyme Q biosynthesis. Stefely JA, et al. Mol Cell, 2015 Jan 8. PMID 25498144, Free PMC Article
    3. Cerebellar Ataxia and Coenzyme Q Deficiency through Loss of Unorthodox Kinase Activity. Stefely JA, et al. Mol Cell, 2016 Aug 18. PMID 27499294, Free PMC Article
    4. Interacting Network of the Gap Junction (GJ) Protein Connexin43 (Cx43) is Modulated by Ischemia and Reperfusion in the Heart. Martins-Marques T, et al. Mol Cell Proteomics, 2015 Nov. PMID 26316108, Free PMC Article
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109473

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ADP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ADP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    NOT enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    NOT involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ubiquinone biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquinone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquinone biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquinone biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    atypical kinase COQ8A, mitochondrial
    Names
    aarF domain containing kinase 3
    aarF domain-containing protein kinase 3
    atypical kinase ADCK3, mitochondrial
    chaperone activity of bc1 complex-like, mitochondrial
    chaperone, ABC1 activity of bc1 complex like
    coenzyme Q protein 8A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013185.1 → NP_001013203.1  atypical kinase COQ8A, mitochondrial

      See identical proteins and their annotated locations for NP_001013203.1

      Status: VALIDATED

      Source sequence(s)
      BC091388
      UniProtKB/Swiss-Prot
      Q5BJQ0
      UniProtKB/TrEMBL
      A0A8L2R303, A6JGG2
      Related
      ENSRNOP00000036948.4, ENSRNOT00000030135.6
      Conserved Domains (1) summary
      cd13970
      Location:296 → 546
      ABC1_ADCK3; Activator of bc1 complex (ABC1) kinases, also called aarF domain containing kinase 3

    2. NM_001429620.1 → NP_001416549.1  atypical kinase COQ8A, mitochondrial

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/Swiss-Prot
      Q5BJQ0
      UniProtKB/TrEMBL
      A0A8L2R303, A6JGG2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      94436680..94465535 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006250387.2 → XP_006250449.1  atypical kinase COQ8A, mitochondrial isoform X1

      Conserved Domains (1) summary
      cd13970
      Location:296 → 546
      ABC1_ADCK3; Activator of bc1 complex (ABC1) kinases, also called aarF domain containing kinase 3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5BJQ0.1 GenPept UniProtKB/Swiss-Prot:Q5BJQ0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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