Slc22a13 solute carrier family 22 member 13 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc22a13provided by RGD
Official Full Name: solute carrier family 22 member 13provided by RGD
Primary source: RGD:1306840
See related: EnsemblRapid:ENSRNOG00000056476 AllianceGenome:RGD:1306840
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: OAT10; ORCTL-3
Summary: Predicted to enable nicotinate transmembrane transporter activity and urate transmembrane transporter activity. Predicted to be involved in several processes, including nicotinate transport; positive regulation of T cell mediated cytotoxicity directed against tumor cell target; and urate transport. Predicted to be located in Golgi apparatus; apical plasma membrane; and endoplasmic reticulum. Orthologous to human SLC22A13 (solute carrier family 22 member 13). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 209.6) and Adrenal (RPKM 8.5) See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (127800097..127811750, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (118922367..118934020, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (127885268..127900829, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of SLC22A13 in basolateral membrane of renal collecting duct stimulates efflux of aspartate and glutamate.
Title: SLC22A13 catalyses unidirectional efflux of aspartate and glutamate at the basolateral membrane of type A intercalated cells in the renal collecting duct.
SLC22A13 is a new urate and high affinity nicotinate transporter
Title: Identification of a new urate and high affinity nicotinate transporter, hOAT10 (SLC22A13).

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables nicotinate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables urate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in negative regulation of fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in nicotinate transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell mediated cytotoxicity directed against tumor cell target	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
NOT involved_in urate transport	ISO Inferred from Sequence Orthology more info
involved_in urate transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: solute carrier family 22 member 13

Names: organic anion transporter 10; organic cation transporter-like 3; solute carrier family 22 (organic anion transporter), member 13; solute carrier family 22 (organic anion/urate transporter), member 13; solute carrier family 22 (organic cation transporter), member 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001126285.1 → NP_001119757.1 solute carrier family 22 member 13

See identical proteins and their annotated locations for NP_001119757.1

Status: PROVISIONAL

Source sequence(s)

BC166511

UniProtKB/Swiss-Prot

B2GV36

UniProtKB/TrEMBL

A0A8I6A5H4

Related

ENSRNOP00000075628.1, ENSRNOT00000078303.3

Conserved Domains (2) summary

cd06174
Location:139 → 500

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

TIGR00898
Location:12 → 510

2A0119; cation transport protein