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    Podxl podocalyxin-like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 192181, updated on 9-Dec-2024

    Summary

    Official Symbol
    Podxlprovided by RGD
    Official Full Name
    podocalyxin-likeprovided by RGD
    Primary source
    RGD:621878
    See related
    EnsemblRapid:ENSRNOG00000012495 AllianceGenome:RGD:621878
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PC; PCLP-1; podocalyxin
    Summary
    Involved in negative regulation of cell adhesion and podocyte development. Located in apical plasma membrane; cell body; and slit diaphragm. Orthologous to human PODXL (podocalyxin like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 453.2), Lung (RPKM 207.5) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Podxl in Genome Data Viewer
    Location:
    4q22
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (61102434..61149131, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (60135124..60181829, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (58829049..58893353, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102486 Neighboring gene muskelin 1 Neighboring gene peptidylprolyl isomerase D, pseudogene 6 Neighboring gene developmental pluripotency-associated 4, pseudogene 8 Neighboring gene uncharacterized LOC134486572 Neighboring gene uncharacterized LOC134486747 Neighboring gene ribosomal protein L38 like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cell adhesion  
    involved_in cell migration  
    involved_in cell migration  
    involved_in cell migration  
    involved_in cell migration  
    involved_in epithelial tube formation  
    involved_in epithelial tube formation  
    involved_in glomerular filtration PubMed 
    acts_upstream_of_or_within leukocyte migration  
    involved_in negative regulation of cell adhesion PubMed 
    involved_in negative regulation of cell adhesion  
    involved_in negative regulation of cell-cell adhesion  
    involved_in negative regulation of cell-cell adhesion  
    involved_in negative regulation of cell-cell adhesion  
    involved_in podocyte development PubMed 
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cell-cell adhesion mediated by integrin  
    involved_in positive regulation of cell-cell adhesion mediated by integrin  
    involved_in positive regulation of cell-cell adhesion mediated by integrin  
    involved_in regulation of cell-cell adhesion  
    involved_in regulation of microvillus assembly  
    involved_in regulation of microvillus assembly  
    involved_in regulation of microvillus assembly  
    involved_in regulation of synapse assembly  
    Items 1 - 20 of 30
    Component Evidence Code Pubs
    is_active_in apical plasma membrane  
    located_in apical plasma membrane PubMed 
    located_in apical plasma membrane  
    located_in apical plasma membrane  
    located_in cell body PubMed 
    located_in centriolar satellite  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in extracellular exosome  
    located_in filopodium  
    located_in filopodium  
    located_in filopodium  
    is_active_in glutamatergic synapse  
    located_in intracellular membrane-bounded organelle  
    located_in lamellipodium  
    located_in lamellipodium  
    located_in lamellipodium  
    located_in membrane raft  
    located_in microvillus  
    is_active_in microvillus membrane  
    located_in microvillus membrane  
    located_in microvillus membrane  
    located_in nucleolus  
    located_in plasma membrane  
    located_in plasma membrane  
    is_active_in presynaptic membrane  
    located_in ruffle  
    located_in ruffle  
    located_in ruffle  
    located_in slit diaphragm PubMed 
    Items 1 - 20 of 30

    General protein information

    Preferred Names
    podocalyxin
    Names
    podocalyxin-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138848.1NP_620203.1  podocalyxin precursor

      See identical proteins and their annotated locations for NP_620203.1

      Status: PROVISIONAL

      Source sequence(s)
      AF109393
      UniProtKB/Swiss-Prot
      Q6IRK7, Q9R068, Q9WTQ2
      UniProtKB/TrEMBL
      A0A8I5YBT0, A6IEJ5
      Related
      ENSRNOP00000075234.2, ENSRNOT00000077406.3
      Conserved Domains (1) summary
      pfam06365
      Location:285484
      CD34_antigen; CD34/Podocalyxin family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      61102434..61149131 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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