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    Helz2 helicase with zinc finger 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296474, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Helz2provided by RGD
    Official Full Name
    helicase with zinc finger 2provided by RGD
    Primary source
    RGD:1306056
    See related
    EnsemblRapid:ENSRNOG00000013267 AllianceGenome:RGD:1306056
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pric285; RGD1306056
    Summary
    Predicted to enable exoribonuclease II activity; helicase activity; and nuclear receptor coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm. Orthologous to human HELZ2 (helicase with zinc finger 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 130.8), Spleen (RPKM 126.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Helz2 in Genome Data Viewer
    Location:
    3q43
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (188716370..188730776, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (168338813..168353219, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (176730024..176744382, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108350541 Neighboring gene src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites Neighboring gene fibronectin type III domain containing 11 Neighboring gene uncharacterized LOC120101833 Neighboring gene glucocorticoid modulatory element binding protein 2 Neighboring gene regulator of telomere elongation helicase 1 Neighboring gene stathmin 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of a transcriptional cofactor and its novel isoform that bind the deoxyribonucleic acid-binding domain of peroxisome proliferator-activated receptor-gamma. Tomaru T, et al. Endocrinology, 2006 Jan. PMID 16239304
    2. Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator. Surapureddi S, et al. Proc Natl Acad Sci U S A, 2002 Sep 3. PMID 12189208, Free PMC Article
    3. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. characterization of Pric285 as a coactivator and as a transcriptionally active peroxisome proliferator-activated receptor alpha-interacting cofactor complex in rat liver.
      Title: Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 5'-3' DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables exoribonuclease II activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear receptor coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    3'-5' exoribonuclease HELZ2
    Names
    helicase with zinc finger 2, transcriptional coactivator
    helicase with zinc finger domain 2
    peroxisomal proliferator-activated receptor A interacting complex 285
    peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein
    NP_001292205.1
    XP_038960623.1
    XP_063139513.1
    XP_063139514.1
    XP_063139515.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305276.1 → NP_001292205.1  3'-5' exoribonuclease HELZ2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I5ZPT9, A0A8I6AGQ7
      Related
      ENSRNOP00000080222.1, ENSRNOT00000113133.2
      Conserved Domains (4) summary
      smart00955
      Location:1565 → 1923
      RNB; This domain is the catalytic domain of ribonuclease II
      cd18040
      Location:2446 → 2721
      DEXXc_HELZ2-C; C-terminal DEXX-box helicase domain of HELZ2
      pfam13087
      Location:2701 → 2906
      AAA_12; AAA domain
      cl28899
      Location:759 → 989
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      188716370..188730776 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104695.2 → XP_038960623.1  3'-5' exoribonuclease HELZ2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZPT9, A0A8I6AGQ7
      Conserved Domains (4) summary
      smart00955
      Location:1565 → 1923
      RNB; This domain is the catalytic domain of ribonuclease II
      cd18040
      Location:2446 → 2721
      DEXXc_HELZ2-C; C-terminal DEXX-box helicase domain of HELZ2
      pfam13087
      Location:2701 → 2906
      AAA_12; AAA domain
      cl28899
      Location:759 → 989
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

    2. XM_063283444.1 → XP_063139514.1  3'-5' exoribonuclease HELZ2 isoform X3

      UniProtKB/TrEMBL
      A0A8I6GD78
      Related
      ENSRNOP00000101102.1, ENSRNOT00000137502.1

    3. XM_063283443.1 → XP_063139513.1  3'-5' exoribonuclease HELZ2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GD78
      Related
      ENSRNOP00000085706.1, ENSRNOT00000118980.2

    4. XM_063283445.1 → XP_063139515.1  3'-5' exoribonuclease HELZ2 isoform X4

      UniProtKB/TrEMBL
      A0A8I6GD78
    Nucleotide Protein Strain
    Heading Accession and Version

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