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    Heatr4 HEAT repeat containing 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500692, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Heatr4provided by RGD
    Official Full Name
    HEAT repeat containing 4provided by RGD
    Primary source
    RGD:1566220
    See related
    EnsemblRapid:ENSRNOG00000038183 AllianceGenome:RGD:1566220
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1566220
    Summary
    Predicted to enable oxidoreductase activity. Orthologous to human HEATR4 (HEAT repeat containing 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 137.9) and Thymus (RPKM 5.6) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Heatr4 in Genome Data Viewer
    Location:
    6q31
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (109305459..109338331, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (103574360..103611578, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (107423214..107460450, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene presenilin 1 Neighboring gene papilin, proteoglycan-like sulfated glycoprotein Neighboring gene NUMB, endocytic adaptor protein Neighboring gene uncharacterized LOC134479228 Neighboring gene uncharacterized LOC134479229 Neighboring gene ribosomal oxygenase 1 Neighboring gene acyl-CoA thioesterase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    HEAT repeat containing 4; HEAT repeat-containing protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001432104.1 → NP_001419033.1  HEAT repeat containing 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      D3ZSB9

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      109305459..109338331 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006240361.5 → XP_006240423.1  HEAT repeat-containing protein 4 isoform X2

      Related
      ENSRNOP00000054933.5, ENSRNOT00000058127.6
      Conserved Domains (2) summary
      pfam13646
      Location:680 → 802
      HEAT_2; HEAT repeats
      sd00044
      Location:681 → 708
      HEAT; HEAT repeat [structural motif]

    2. XM_063262680.1 → XP_063118750.1  HEAT repeat-containing protein 4 isoform X1

    3. XM_006240362.4 → XP_006240424.1  HEAT repeat-containing protein 4 isoform X2

      See identical proteins and their annotated locations for XP_006240424.1

      UniProtKB/TrEMBL
      D3ZSB9
      Related
      ENSRNOP00000100901.1, ENSRNOT00000130457.1
      Conserved Domains (2) summary
      pfam13646
      Location:680 → 802
      HEAT_2; HEAT repeats
      sd00044
      Location:681 → 708
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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