U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Hars1 histidyl-tRNA synthetase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307492, updated on 9-Dec-2024

    Summary

    Official Symbol
    Hars1provided by RGD
    Official Full Name
    histidyl-tRNA synthetase 1provided by RGD
    Primary source
    RGD:1310695
    See related
    EnsemblRapid:ENSRNOG00000028105 AllianceGenome:RGD:1310695
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dnd1; Hars
    Summary
    Predicted to enable several functions, including ATP binding activity; histidine-tRNA ligase activity; and protein homodimerization activity. Predicted to be involved in histidyl-tRNA aminoacylation and mitochondrial translation. Predicted to be located in cytoplasm. Predicted to be active in cytosol and mitochondrion. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease, axonal type 2W and Usher syndrome type 3B. Orthologous to human HARS1 (histidyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 222.8), Adrenal (RPKM 176.7) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Hars1 in Genome Data Viewer
    Location:
    18p11
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (28655669..28672712, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (28381649..28398699, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (29611545..29629087, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene IK cytokine Neighboring gene WD repeat domain 55 Neighboring gene DND microRNA-mediated repression inhibitor 1 Neighboring gene small nucleolar RNA SNORA72 Neighboring gene histidyl-tRNA synthetase 2, mitochondrial Neighboring gene zinc finger, matrin type 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables RNA binding  
    enables histidine-tRNA ligase activity  
    enables histidine-tRNA ligase activity  
    enables identical protein binding  
    enables identical protein binding  
    enables protein homodimerization activity  
    Process Evidence Code Pubs
    involved_in histidyl-tRNA aminoacylation  
    involved_in histidyl-tRNA aminoacylation  
    involved_in mitochondrial translation  
    Component Evidence Code Pubs
    located_in cytoplasm  
    is_active_in cytosol  
    located_in cytosol  
    is_active_in mitochondrion  

    General protein information

    Preferred Names
    histidine--tRNA ligase, cytoplasmic
    Names
    dead end homolog 1
    histidyl-tRNA synthetase, cytoplasmic
    NP_001020585.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025414.1NP_001020585.1  histidine--tRNA ligase, cytoplasmic

      See identical proteins and their annotated locations for NP_001020585.1

      Status: PROVISIONAL

      Source sequence(s)
      BC097969
      UniProtKB/TrEMBL
      A0A8J8YFS5, F1LPB1, Q4QQV4
      Related
      ENSRNOP00000034118.7, ENSRNOT00000039291.7
      Conserved Domains (4) summary
      COG0124
      Location:56501
      HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
      cd00773
      Location:69394
      HisRS-like_core; Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...
      cd00859
      Location:408499
      HisRS_anticodon; HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...
      cd00938
      Location:549
      HisRS_RNA; HisRS_RNA binding domain. This short RNA-binding domain is found at the N-terminus of HisRS in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). This domain consists of a helix- turn- helix structure, which is similar to other RNA-binding ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      28655669..28672712 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    External link. Please review our privacy policy.