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    Dnaja4 DnaJ heat shock protein family (Hsp40) member A4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300721, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dnaja4provided by RGD
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member A4provided by RGD
    Primary source
    RGD:1310035
    See related
    EnsemblRapid:ENSRNOG00000012106 AllianceGenome:RGD:1310035
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein-folding chaperone binding activity and unfolded protein binding activity. Predicted to be involved in several processes, including negative regulation of endothelial cell migration; negative regulation of inclusion body assembly; and protein refolding. Predicted to be located in membrane. Predicted to be active in cytosol. Orthologous to human DNAJA4 (DnaJ heat shock protein family (Hsp40) member A4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 692.5), Muscle (RPKM 548.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dnaja4 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (63975177..63998836)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (55085246..55102715)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (59278262..59294003)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha Neighboring gene acyl-CoA synthetase bubblegum family member 1 Neighboring gene SKI8 subunit of superkiller complex Neighboring gene cellular retinoic acid binding protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Convergent multi-miRNA targeting of ApoE drives LRP1/LRP8-dependent melanoma metastasis and angiogenesis. Pencheva N, et al. Cell, 2012 Nov 21. PMID 23142051, Free PMC Article
    2. Induction of molecular chaperones in carbon tetrachloride-treated rat liver: implications in protection against liver damage. Lee KJ, et al. Cell Stress Chaperones, 2004 Mar. PMID 15270078, Free PMC Article
    3. The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities. Hageman J, et al. Biochem J, 2011 Apr 1. PMID 21231916
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Hsp70 protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-folding chaperone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables unfolded protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of inclusion body assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein refolding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to heat IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dnaJ homolog subfamily A member 4
    Names
    DnaJ (Hsp40) homolog, subfamily A, member 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025411.2 → NP_001020582.1  dnaJ homolog subfamily A member 4

      See identical proteins and their annotated locations for NP_001020582.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      Q4QR73
      Related
      ENSRNOP00000101156.1, ENSRNOT00000167883.1
      Conserved Domains (4) summary
      cd10719
      Location:293 → 359
      DnaJ_zf; Zinc finger domain of DnaJ and HSP40
      cd10747
      Location:264 → 490
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      PTZ00037
      Location:144 → 552
      PTZ00037; DnaJ_C chaperone protein; Provisional
      pfam00226
      Location:165 → 223
      DnaJ; DnaJ domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      63975177..63998836
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081075.2 → XP_038937003.1  dnaJ homolog subfamily A member 4 isoform X1

      Conserved Domains (2) summary
      PHA03247
      Location:8 → 126
      PHA03247; large tegument protein UL36; Provisional
      PTZ00037
      Location:144 → 451
      PTZ00037; DnaJ_C chaperone protein; Provisional

    2. XM_063265117.1 → XP_063121187.1  dnaJ homolog subfamily A member 4 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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