Gba3 glucosylceramidase beta 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gba3provided by RGD
Official Full Name: glucosylceramidase beta 3provided by RGD
Primary source: RGD:1309539
See related: EnsemblRapid:ENSRNOG00000024634 AllianceGenome:RGD:1309539
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable hydrolase activity, hydrolyzing O-glycosyl compounds. Predicted to be involved in several processes, including glycosylceramide catabolic process; positive regulation of exo-alpha-sialidase activity; and protein stabilization. Predicted to be part of catalytic complex. Predicted to be active in cytosol. Orthologous to human GBA3 (glucosylceramidase beta 3 (gene/pseudogene)). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 660.0) See more
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Genomic context

Location:: 14q11

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (64787601..64934043, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (60574974..60721411, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (64390793..64535213, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GBA3 promotes fatty acid oxidation and alleviates non-alcoholic fatty liver by increasing CPT2 transcription.
Title: GBA3 promotes fatty acid oxidation and alleviates non-alcoholic fatty liver by increasing CPT2 transcription.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables beta-galactosidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables beta-galactosidase activity	ISO Inferred from Sequence Orthology more info
enables beta-glucosidase activity	ISO Inferred from Sequence Orthology more info
enables galactosylceramidase activity	ISO Inferred from Sequence Orthology more info
enables glucosylceramidase activity	ISO Inferred from Sequence Orthology more info
enables glycosylceramidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycosylceramidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in beta-glucoside catabolic process	ISO Inferred from Sequence Orthology more info
involved_in galactosylceramide catabolic process	ISO Inferred from Sequence Orthology more info
NOT involved_in glucosylceramide catabolic process	ISO Inferred from Sequence Orthology more info
involved_in glucosylceramide catabolic process	ISO Inferred from Sequence Orthology more info
involved_in glycoside catabolic process	ISO Inferred from Sequence Orthology more info
involved_in glycosylceramide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in oligosaccharide catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of exo-alpha-sialidase activity	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of catalytic complex	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glucosylceramidase beta 3

Names: cytosolic beta-glucosidase; glucosidase, beta, acid 3 (cytosolic)

NP_001382556.1

EC 3.2.1.21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001395627.1 → NP_001382556.1 glucosylceramidase beta 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/TrEMBL

A0A0G2JVP8, G3V8Y1

Related

ENSRNOP00000069571.2, ENSRNOT00000082338.3

Conserved Domains (1) summary

cl23725
Location:4 → 456

Glyco_hydro; Glycosyl hydrolases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

64787601..64934043 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001106010.1: Suppressed sequence

Description

NM_001106010.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.