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    Ncl nucleolin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25135, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nclprovided by RGD
    Official Full Name
    nucleolinprovided by RGD
    Primary source
    RGD:3153
    See related
    EnsemblRapid:ENSRNOG00000018273 AllianceGenome:RGD:3153
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables several functions, including ErbB-4 class receptor binding activity; calcium ion binding activity; and nucleic acid binding activity. Involved in several processes, including cellular response to lipopolysaccharide; liver regeneration; and regulation of gene expression. Located in cell surface; dense fibrillar component; and fibrillar center. Orthologous to human NCL (nucleolin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 490.1), Thymus (RPKM 465.0) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ncl in Genome Data Viewer
    Location:
    9q35
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (94447559..94456083, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (86999588..87008112, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (93369119..93377643, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548542 Neighboring gene transfer RNA proline (anticodon AGG) 49 Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 Neighboring gene small nucleolar RNA, H/ACA box 75 Neighboring gene small nucleolar RNA, C/D box 20 Neighboring gene small nucleolar RNA, C/D box 82 Neighboring gene neuromedin U receptor 1 Neighboring gene testis expressed 44

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Clone Names

    • MGC93572

    Gene Ontology Provided by RGD

    Items 1 - 25 of 29
    Function Evidence Code Pubs
    enables DNA binding  
    enables DNA topoisomerase binding  
    enables DNA topoisomerase binding  
    enables ErbB-4 class receptor binding PubMed 
    enables PH domain binding  
    enables PH domain binding  
    enables RNA binding  
    enables RNA binding PubMed 
    enables RNA binding  
    enables RNA binding  
    enables RNA binding  
    enables calcium ion binding PubMed 
    enables histone binding PubMed 
    enables identical protein binding  
    enables identical protein binding  
    enables insulin receptor substrate binding  
    enables insulin receptor substrate binding  
    enables laminin binding PubMed 
    enables mRNA 5'-UTR binding  
    enables mRNA 5'-UTR binding  
    enables protein binding PubMed 
    enables rRNA primary transcript binding PubMed 
    enables selenocysteine insertion sequence binding PubMed 
    enables sequence-specific DNA binding PubMed 
    enables signaling receptor binding PubMed 
    enables single-stranded DNA binding PubMed 
    enables telomeric DNA binding  
    enables telomeric DNA binding  
    enables telomeric DNA binding  
    Items 1 - 25 of 29
    Process Evidence Code Pubs
    involved_in angiogenesis  
    involved_in angiogenesis  
    involved_in cellular response to epidermal growth factor stimulus  
    acts_upstream_of_or_within cellular response to epidermal growth factor stimulus  
    involved_in cellular response to leukemia inhibitory factor  
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor  
    involved_in cellular response to lipopolysaccharide PubMed 
    involved_in endocytosis PubMed 
    involved_in liver regeneration PubMed 
    involved_in negative regulation of apoptotic process PubMed 
    involved_in negative regulation of insulin receptor signaling pathway  
    acts_upstream_of_or_within negative regulation of insulin receptor signaling pathway  
    involved_in negative regulation of translation  
    involved_in negative regulation of translation  
    involved_in positive regulation of interleukin-6 production PubMed 
    involved_in positive regulation of mRNA splicing, via spliceosome  
    involved_in positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription of nucleolar large rRNA by RNA polymerase I  
    involved_in positive regulation of transcription of nucleolar large rRNA by RNA polymerase I  
    involved_in positive regulation of tumor necrosis factor production PubMed 
    acts_upstream_of_or_within regulation of peptidyl-tyrosine phosphorylation  
    involved_in regulation of rRNA processing PubMed 
    involved_in spermatogenesis PubMed 
    Component Evidence Code Pubs
    located_in cell cortex  
    located_in cell cortex  
    located_in cell surface PubMed 
    located_in chromosome  
    located_in chromosome  
    located_in cornified envelope  
    is_active_in cornified envelope  
    located_in cytoplasmic ribonucleoprotein granule  
    located_in cytoplasmic ribonucleoprotein granule  
    located_in dense fibrillar component PubMed 
    located_in fibrillar center PubMed 
    located_in nucleolus  
    located_in nucleolus  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus  
    part_of ribonucleoprotein complex  
    part_of ribonucleoprotein complex  
    part_of ribonucleoprotein complex  
    part_of spliceosomal complex  

    General protein information

    Preferred Names
    nucleolin
    Names
    nucleolin-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012749.2NP_036881.2  nucleolin

      See identical proteins and their annotated locations for NP_036881.2

      Status: PROVISIONAL

      Source sequence(s)
      BC085751
      UniProtKB/Swiss-Prot
      P13383
      UniProtKB/TrEMBL
      A6JWG9, F7EJZ2, Q5U328
      Related
      ENSRNOP00000076825.2, ENSRNOT00000118117.2
      Conserved Domains (4) summary
      cd12403
      Location:312386
      RRM1_NCL; RNA recognition motif 1 in vertebrate nucleolin
      cd12404
      Location:395470
      RRM2_NCL; RNA recognition motif 2 in vertebrate nucleolin
      cd12405
      Location:489561
      RRM3_NCL; RNA recognition motif 3 in vertebrate nucleolin
      cd12406
      Location:576653
      RRM4_NCL; RNA recognition motif 4 in vertebrate nucleolin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      94447559..94456083 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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