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    Net1 neuroepithelial cell transforming 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307098, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Net1provided by RGD
    Official Full Name
    neuroepithelial cell transforming 1provided by RGD
    Primary source
    RGD:1305034
    See related
    EnsemblRapid:ENSRNOG00000017765 AllianceGenome:RGD:1305034
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including cellular response to hydrogen peroxide; positive regulation of GTPase activity; and positive regulation of Rho protein signal transduction. Predicted to act upstream of or within myoblast migration. Predicted to be located in cytoplasm. Orthologous to human NET1 (neuroepithelial cell transforming 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 413.1), Lung (RPKM 408.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Net1 in Genome Data Viewer
    Location:
    17q12.2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (71251145..71280345)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (66341251..66370445)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (69991786..70020977)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene urocortin 3 Neighboring gene tubulin, alpha-like 3 Neighboring gene uncharacterized LOC134482593 Neighboring gene uncharacterized LOC134482594 Neighboring gene uncharacterized LOC103694125

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rac1 controls the subcellular localization of the Rho guanine nucleotide exchange factor Net1A to regulate focal adhesion formation and cell spreading. Carr HS, et al. Mol Cell Biol, 2013 Feb. PMID 23184663, Free PMC Article
    2. The nuclear guanine nucleotide exchange factors Ect2 and Net1 regulate RhoB-mediated cell death after DNA damage. Srougi MC, et al. PLoS One, 2011 Feb 23. PMID 21373644, Free PMC Article
    3. Autonomous and nonautonomous roles of Hedgehog signaling in regulating limb muscle formation. Hu JK, et al. Genes Dev, 2012 Sep 15. PMID 22987639, Free PMC Article
    4. The sclerostin-bone protein interactome. Devarajan-Ketha H, et al. Biochem Biophys Res Commun, 2012 Jan 13. PMID 22206666, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC114559

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within myoblast migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    neuroepithelial cell-transforming gene 1 protein
    Names
    neuroepithelial cell transforming gene 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039023.1 → NP_001034112.1  neuroepithelial cell-transforming gene 1 protein

      See identical proteins and their annotated locations for NP_001034112.1

      Status: PROVISIONAL

      Source sequence(s)
      BC100154
      UniProtKB/TrEMBL
      A6JLQ2, Q498M6
      Related
      ENSRNOP00000023945.2, ENSRNOT00000023945.6
      Conserved Domains (3) summary
      smart00325
      Location:124 → 300
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd13224
      Location:314 → 448
      PH_Net1; Neuroepithelial cell transforming 1 Pleckstrin homology (PH) domain
      pfam00169
      Location:333 → 447
      PH; PH domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      71251145..71280345
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006254206.5 → XP_006254268.1  neuroepithelial cell-transforming gene 1 protein isoform X1

      UniProtKB/TrEMBL
      A0A8I6AVA8
      Related
      ENSRNOP00000102206.1, ENSRNOT00000170244.1
      Conserved Domains (3) summary
      smart00325
      Location:178 → 354
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd13224
      Location:368 → 502
      PH_Net1; Neuroepithelial cell transforming 1 Pleckstrin homology (PH) domain
      pfam00169
      Location:387 → 501
      PH; PH domain
    Nucleotide Protein Strain
    Heading Accession and Version

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