Ppp1r3c protein phosphatase 1, regulatory subunit 3C [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Ppp1r3cprovided by RGD
Full Name: protein phosphatase 1, regulatory subunit 3Cprovided by RGD
Primary source: RGD:1309132
See related: AllianceGenome:RGD:1309132
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: R5; PTG
Summary: Enables [phosphorylase] phosphatase activity and enzyme binding activity. Contributes to phosphoprotein phosphatase activity. Involved in regulation of glycogen biosynthetic process and regulation of glycogen catabolic process. Located in glycogen granule. Orthologous to human PPP1R3C (protein phosphatase 1 regulatory subunit 3C). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 1044.3), Liver (RPKM 443.3) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q53

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (243873524..243878527, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (234460958..234465961, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (255371830..255376833, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH127645 (e-PCR)
- UniSTS:210955

RH138361 (e-PCR)
- UniSTS:220448

RH129209 (e-PCR)
- UniSTS:212517

AA800273 (e-PCR)
- UniSTS:261434

RH140525 (e-PCR)
- UniSTS:222594

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables [phosphorylase] phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables enzyme binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables glycogen binding	IBA Inferred from Biological aspect of Ancestor more info
enables glycogen binding	IEA Inferred from Electronic Annotation more info
enables glycogen binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	IEA Inferred from Electronic Annotation more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
contributes_to phosphoprotein phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein phosphatase 1 binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase binding	IEA Inferred from Electronic Annotation more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in glycogen biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glycogen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in glycogen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in glycogen biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within glycogen metabolic process	ISO Inferred from Sequence Orthology more info
involved_in glycogen metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of glycogen biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of glycogen biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of glycogen catabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in glycogen granule	IDA Inferred from Direct Assay more info	PubMed
part_of protein phosphatase type 1 complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein phosphatase 1 regulatory subunit 3C

Names: PP1 subunit R5; protein phosphatase 1 regulatory subunit 3C-like; protein phosphatase 1 regulatory subunit 5; protein phosphatase 1, regulatory (inhibitor) subunit 3C; protein targeting to glycogen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012072.1 → NP_001012072.1 protein phosphatase 1 regulatory subunit 3C

See identical proteins and their annotated locations for NP_001012072.1

Status: PROVISIONAL

Source sequence(s)

BC085894

UniProtKB/Swiss-Prot

Q5U2R5

UniProtKB/TrEMBL

A6I157, G3V8E0

Conserved Domains (1) summary

pfam03370
Location:151 → 256

CBM_21; Carbohydrate/starch-binding module (family 21)