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    Slc45a4 solute carrier family 45, member 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315054, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Slc45a4provided by RGD
    Official Full Name
    solute carrier family 45, member 4provided by RGD
    Primary source
    RGD:1309971
    See related
    EnsemblRapid:ENSRNOG00000007818 AllianceGenome:RGD:1309971
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309971
    Summary
    Predicted to enable sucrose:proton symporter activity. Predicted to be involved in transmembrane transport. Predicted to act upstream of or within sucrose transport. Predicted to be active in membrane. Orthologous to human SLC45A4 (solute carrier family 45 member 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 49.0), Adrenal (RPKM 44.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc45a4 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (107370826..107459163, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (105478886..105550160, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (114817817..114888998, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L36 like 1 Neighboring gene DENN domain containing 3 Neighboring gene uncharacterized LOC134479924 Neighboring gene G protein-coupled receptor 20

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Proton-associated sucrose transport of mammalian solute carrier family 45: an analysis in Saccharomyces cerevisiae. Bartölke R, et al. Biochem J, 2014 Dec 1. PMID 25164149
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables sucrose:proton symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sucrose:proton symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within sucrose transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 45 member 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      107370826..107459163 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264631.1 → XP_063120701.1  solute carrier family 45 member 4

      UniProtKB/TrEMBL
      A6HRV7, D4ADC6

    2. XM_039080226.2 → XP_038936154.1  solute carrier family 45 member 4

      UniProtKB/TrEMBL
      A6HRV7, D4ADC6
      Related
      ENSRNOP00000029754.6, ENSRNOT00000032620.8
      Conserved Domains (1) summary
      cl28910
      Location:53 → 275
      MFS; Major Facilitator Superfamily

    3. XM_006241741.5 → XP_006241803.1  solute carrier family 45 member 4

      See identical proteins and their annotated locations for XP_006241803.1

      UniProtKB/TrEMBL
      A6HRV7, D4ADC6
      Conserved Domains (1) summary
      cl28910
      Location:53 → 275
      MFS; Major Facilitator Superfamily

    4. XM_039080227.2 → XP_038936155.1  solute carrier family 45 member 4

      UniProtKB/TrEMBL
      A6HRV7, D4ADC6
      Conserved Domains (1) summary
      cl28910
      Location:53 → 275
      MFS; Major Facilitator Superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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