Efhd2 EF-hand domain family, member D2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Efhd2provided by RGD
Official Full Name: EF-hand domain family, member D2provided by RGD
Primary source: RGD:1307585
See related: AllianceGenome:RGD:1307585
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable calcium ion binding activity. Predicted to be located in membrane raft. Orthologous to human EFHD2 (EF-hand domain family member D2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 382.0), Lung (RPKM 319.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (159443959..159459993, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (154160945..154176980, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (160407777..160423811, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Swiprosin-1/EFhD-2 Expression in Cardiac Remodeling and Post-Infarct Repair: Effect of Ischemic Conditioning.
Title: Swiprosin-1/EFhD-2 Expression in Cardiac Remodeling and Post-Infarct Repair: Effect of Ischemic Conditioning.
Study reports that adult rat ventricular cardiomyocytes (ARVC) constitutively express swiprosin-1 on mRNA and protein level and that swiprosin-1 is required to initiate the formation of pseudopodia-like structures (spreading), a process necessary to adapt to culture conditions. Also, the expression level of swiprosin-1 is associated to that of GRK2 and thereby to beta-adrenoceptor responsiveness.
Title: The Effects of Swiprosin-1 on the Formation of Pseudopodia-Like Structures and β-Adrenoceptor Coupling in Cultured Adult Rat Ventricular Cardiomyocytes.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G46597 (e-PCR)
- UniSTS:107398

RH129339 (e-PCR)
- UniSTS:212646

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane raft	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: EF-hand domain-containing protein D2

Names: EF hand domain containing 2; swiprosin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001031648.1 → NP_001026818.1 EF-hand domain-containing protein D2

See identical proteins and their annotated locations for NP_001026818.1

Status: PROVISIONAL

Source sequence(s)

BC098936

UniProtKB/Swiss-Prot

Q4FZY0

UniProtKB/TrEMBL

A6ITX6

Conserved Domains (1) summary

cd00051
Location:95 → 153

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...