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    Trpm1 transient receptor potential cation channel, subfamily M, member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361586, updated on 9-Dec-2024

    Summary

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    Symbol
    Trpm1provided by RGD
    Full Name
    transient receptor potential cation channel, subfamily M, member 1provided by RGD
    Primary source
    RGD:1597140
    See related
    EnsemblRapid:ENSRNOG00000015829 AllianceGenome:RGD:1597140
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable calcium channel activity. Predicted to be involved in G protein-coupled glutamate receptor signaling pathway; calcium ion import across plasma membrane; and visual perception. Predicted to act upstream of or within several processes, including cellular response to light stimulus; protein localization; and retinal rod cell development. Predicted to be located in endoplasmic reticulum and new growing cell tip. Predicted to be active in cell tip; dendrite; and plasma membrane. Human ortholog(s) of this gene implicated in congenital stationary night blindness and congenital stationary night blindness 1C. Orthologous to human TRPM1 (transient receptor potential cation channel subfamily M member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 13.6), Testes (RPKM 10.0) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Trpm1 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (127130686..127247219)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (117718896..117835434)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (124983391..125101759)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485125 Neighboring gene uncharacterized LOC120099837 Neighboring gene microRNA 211 Neighboring gene myotubularin related protein 10 Neighboring gene FANCD2 and FANCI associated nuclease 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The characterization of a novel S100A1 binding site in the N-terminus of TRPM1. Jirku M, et al. Int J Biochem Cell Biol, 2016 Sep. PMID 27435061
    2. Genetic variants in transient receptor potential cation channel, subfamily M 1 (TRPM1) and their risk of albuminuria-related traits in Mexican Americans. Thameem F, et al. Clin Chim Acta, 2011 Nov 20. PMID 21439949, Free PMC Article
    3. TRPM1 is mutated in patients with autosomal-recessive complete congenital stationary night blindness. Audo I, et al. Am J Hum Genet, 2009 Nov. PMID 19896113, Free PMC Article
    4. Mutations in TRPM1 are a common cause of complete congenital stationary night blindness. van Genderen MM, et al. Am J Hum Genet, 2009 Nov. PMID 19896109, Free PMC Article
    5. Recessive mutations of the gene TRPM1 abrogate ON bipolar cell function and cause complete congenital stationary night blindness in humans. Li Z, et al. Am J Hum Genet, 2009 Nov. PMID 19878917, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. a molecular mechanism for the potential regulation of TRPM1 by S100A1
      Title: The characterization of a novel S100A1 binding site in the N-terminus of TRPM1.
    2. Polymerase chain reaction used to check the expression of all TRPM and TRPV channel members with specific primers.
      Title: Distribution profiles of transient receptor potential melastatin-related and vanilloid-related channels in prostatic tissue in rat.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables monoatomic cation channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables monoatomic cation transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables monoatomic cation transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables monoatomic ion channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled glutamate receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in G protein-coupled glutamate receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in calcium ion import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in calcium ion import across plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within cellular response to light stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to light stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in metal ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic cation transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic cation transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in monoatomic cation transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in monoatomic cation transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein tetramerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within retinal rod cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in visual perception ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cell tip ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in new growing cell tip ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transient receptor potential cation channel subfamily M member 1
    Names
    melastatin
    melastatin-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037733.1 → NP_001032822.1  transient receptor potential cation channel subfamily M member 1 isoform 2

      See identical proteins and their annotated locations for NP_001032822.1

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      AJ867483
      UniProtKB/Swiss-Prot
      F1M9X0, Q2WEA4, Q2WEA5
      Conserved Domains (3) summary
      pfam00520
      Location:899 → 1129
      Ion_trans; Ion transport protein
      pfam16519
      Location:1228 → 1279
      TRPM_tetra; Tetramerization domain of TRPM
      cl19167
      Location:273 → 342
      Bac_export_2; FlhB HrpN YscU SpaS Family

    2. NM_001037734.1 → NP_001032823.1  transient receptor potential cation channel subfamily M member 1 isoform 1

      See identical proteins and their annotated locations for NP_001032823.1

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
      Source sequence(s)
      AJ867482
      UniProtKB/Swiss-Prot
      F1M9X0, Q2WEA4, Q2WEA5
      Related
      ENSRNOP00000021262.7, ENSRNOT00000021262.8
      Conserved Domains (3) summary
      pfam00520
      Location:899 → 1135
      Ion_trans; Ion transport protein
      pfam16519
      Location:1234 → 1285
      TRPM_tetra; Tetramerization domain of TRPM
      cl19167
      Location:273 → 342
      Bac_export_2; FlhB HrpN YscU SpaS Family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      127130686..127247219
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266876.1 → XP_063122946.1  transient receptor potential cation channel subfamily M member 1 isoform X1

      UniProtKB/Swiss-Prot
      F1M9X0, Q2WEA4, Q2WEA5

    2. XM_039082296.1 → XP_038938224.1  transient receptor potential cation channel subfamily M member 1 isoform X2

      Conserved Domains (2) summary
      TIGR00870
      Location:45 → 443
      trp; transient-receptor-potential calcium channel protein
      pfam16519
      Location:512 → 565
      TRPM_tetra; Tetramerisation domain of TRPM
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2WEA5.2 GenPept UniProtKB/Swiss-Prot:Q2WEA5

    Gene LinkOut

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