Pla2r1 phospholipase A2 receptor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Pla2r1provided by RGD
Full Name: phospholipase A2 receptor 1provided by RGD
Primary source: RGD:1309777
See related: EnsemblRapid:ENSRNOG00000008129 AllianceGenome:RGD:1309777
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable phospholipase binding activity and signaling receptor activity. Predicted to be involved in several processes, including negative regulation of phospholipase A2 activity; oxidative stress-induced premature senescence; and regulation of arachidonate secretion. Predicted to be located in cell surface and extracellular region. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Orthologous to human PLA2R1 (phospholipase A2 receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 24.8), Adrenal (RPKM 22.8) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q21

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (65292629..65422462, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (44883943..45013793, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (46488963..46621873, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Effectiveness of a novel rat model of off-target PLA2R1 knockout to renal impairment.
Title: Effectiveness of a novel rat model of off-target PLA2R1 knockout to renal impairment.

Submit: New GeneRIF Correction

General gene information

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Markers

RH135377 (e-PCR)
- UniSTS:218654

RH133142 (e-PCR)
- UniSTS:216425

AW535150 (e-PCR)
- UniSTS:247189

D3Chm55 (e-PCR)
- UniSTS:265369

D3Chm54 (e-PCR)
- UniSTS:265396

RH129404 (e-PCR)
- UniSTS:212711

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables phospholipase binding	ISO Inferred from Sequence Orthology more info
enables phospholipase binding	ISS Inferred from Sequence or Structural Similarity more info
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in negative regulation of arachidonate secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phospholipase A2 activity	ISO Inferred from Sequence Orthology more info
involved_in oxidative stress-induced premature senescence	ISO Inferred from Sequence Orthology more info
involved_in oxidative stress-induced premature senescence	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA damage response, signal transduction by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA damage response, signal transduction by p53 class mediator	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of arachidonate secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of arachidonate secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of podocyte apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in reactive oxygen species metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in receptor-mediated endocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in replicative senescence	ISO Inferred from Sequence Orthology more info
involved_in replicative senescence	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: secretory phospholipase A2 receptor

Names: secretory phospholipase A2 receptor-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100837.1 → NP_001094307.1 secretory phospholipase A2 receptor precursor

See identical proteins and their annotated locations for NP_001094307.1

Status: PROVISIONAL

Source sequence(s)

CH473983

UniProtKB/TrEMBL

A6JF83, F1M495

Related

ENSRNOP00000011003.6, ENSRNOT00000011003.8

Conserved Domains (4) summary

smart00034
Location:378 → 502

CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)

smart00458
Location:46 → 143

RICIN; Ricin-type beta-trefoil

cd00062
Location:173 → 220

FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...

cd00161
Location:54 → 133

RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

65292629..65422462 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039104479.2 → XP_038960407.1 secretory phospholipase A2 receptor isoform X1

Conserved Domains (1) summary

smart00034
Location:146 → 270

CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
XM_039104480.2 → XP_038960408.1 secretory phospholipase A2 receptor isoform X2

Conserved Domains (3) summary

smart00034
Location:378 → 502

CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)

smart00458
Location:46 → 143

RICIN; Ricin-type beta-trefoil

cd00062
Location:173 → 220

FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...