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    Kif5a kinesin family member 5A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314906, updated on 9-Dec-2024

    Summary

    Official Symbol
    Kif5aprovided by RGD
    Official Full Name
    kinesin family member 5Aprovided by RGD
    Primary source
    RGD:1303035
    See related
    EnsemblRapid:ENSRNOG00000005299 AllianceGenome:RGD:1303035
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables scaffold protein binding activity. Involved in several processes, including axonal transport; cellular response to ethanol; and forebrain development. Located in several cellular components, including P-body; central region of growth cone; and perikaryon. Part of kinesin complex. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 25; hereditary spastic paraplegia 10; multiple sclerosis; prostate cancer; and rheumatoid arthritis. Orthologous to human KIF5A (kinesin family member 5A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 1106.0) See more
    Orthologs
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    Genomic context

    See Kif5a in Genome Data Viewer
    Location:
    7q22
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (64937210..64974339, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (63051894..63089024, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (70515832..70552897, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479708 Neighboring gene deltex E3 ubiquitin ligase 3 Neighboring gene phosphatidylinositol-5-phosphate 4-kinase type 2 gamma Neighboring gene dynactin subunit 2 Neighboring gene methyl-CpG binding domain protein 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables kinesin binding  
    enables kinesin binding  
    enables microtubule binding  
    enables microtubule binding  
    enables microtubule binding  
    enables microtubule motor activity  
    enables microtubule motor activity PubMed 
    enables plus-end-directed microtubule motor activity  
    enables protein binding PubMed 
    enables protein-containing complex binding PubMed 
    enables scaffold protein binding PubMed 
    Process Evidence Code Pubs
    involved_in anterograde axonal protein transport PubMed 
    involved_in anterograde dendritic transport of neurotransmitter receptor complex  
    involved_in anterograde dendritic transport of neurotransmitter receptor complex  
    involved_in anterograde dendritic transport of neurotransmitter receptor complex  
    involved_in axon guidance  
    involved_in cellular response to ethanol PubMed 
    involved_in cellular response to nerve growth factor stimulus PubMed 
    involved_in cerebral cortex development PubMed 
    involved_in hippocampus development PubMed 
    involved_in microtubule-based movement  
    involved_in microtubule-based process PubMed 
    involved_in neuron development PubMed 
    involved_in response to rotenone PubMed 
    involved_in retrograde neuronal dense core vesicle transport PubMed 
    involved_in synaptic vesicle transport  
    involved_in thalamus development PubMed 
    involved_in vesicle-mediated transport  
    involved_in vesicle-mediated transport  
    involved_in vesicle-mediated transport  
    Items 1 - 20 of 25
    Component Evidence Code Pubs
    located_in P-body PubMed 
    located_in apical dendrite PubMed 
    located_in axon PubMed 
    located_in axon cytoplasm  
    located_in central region of growth cone PubMed 
    located_in ciliary rootlet  
    located_in ciliary rootlet  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytoskeleton  
    located_in dendrite PubMed 
    located_in dendrite cytoplasm  
    part_of kinesin complex  
    part_of kinesin complex PubMed 
    part_of kinesin complex PubMed 
    is_active_in microtubule  
    located_in microtubule PubMed 
    located_in neuron projection  
    located_in neuronal cell body  
    located_in neuronal cell body  
    located_in perikaryon PubMed 
    located_in perinuclear region of cytoplasm  
    located_in postsynaptic cytosol  
    is_active_in postsynaptic cytosol  
    Items 1 - 20 of 25

    General protein information

    Preferred Names
    kinesin heavy chain isoform 5A
    Names
    NKHC
    kinesin heavy chain neuron-specific 1
    neuronal kinesin heavy chain

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212523.1NP_997688.1  kinesin heavy chain isoform 5A

      See identical proteins and their annotated locations for NP_997688.1

      Status: PROVISIONAL

      Source sequence(s)
      AY535015
      UniProtKB/Swiss-Prot
      Q6QLM7
      UniProtKB/TrEMBL
      A0A0G2K0Q2
      Related
      ENSRNOP00000071539.1, ENSRNOT00000080594.3
      Conserved Domains (5) summary
      smart00129
      Location:9334
      KISc; Kinesin motor, catalytic domain. ATPase
      cd14798
      Location:441493
      RX-CC_like; Coiled-coil domain of the potato virux X resistance protein and similar proteins
      cd01369
      Location:7327
      KISc_KHC_KIF5; Kinesin motor domain, kinesin heavy chain (KHC) or KIF5-like subgroup
      pfam05010
      Location:713884
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      cl12013
      Location:637809
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      64937210..64974339 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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