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    Btrc beta-transducin repeat containing E3 ubiquitin protein ligase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361765, updated on 27-Dec-2024

    Summary

    Official Symbol
    Btrcprovided by RGD
    Official Full Name
    beta-transducin repeat containing E3 ubiquitin protein ligaseprovided by RGD
    Primary source
    RGD:1359721
    See related
    EnsemblRapid:ENSRNOG00000016280 AllianceGenome:RGD:1359721
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    beta-TrCP1
    Summary
    Predicted to enable several functions, including beta-catenin binding activity; ubiquitin ligase activator activity; and ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in several processes, including protein modification process; regulation of primary metabolic process; and regulation of signal transduction. Predicted to act upstream of or within several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; mammary gland epithelium development; and protein K48-linked ubiquitination. Predicted to be located in cytoplasm and nucleus. Predicted to be part of SCF ubiquitin ligase complex. Orthologous to human BTRC (beta-transducin repeat containing E3 ubiquitin protein ligase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 58.5), Adrenal (RPKM 48.0) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Btrc in Genome Data Viewer
    Location:
    1q54
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (254159085..254324819)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (244210299..244380126)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (265100094..265270263)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100042 Neighboring gene uncharacterized LOC100911827 Neighboring gene uncharacterized LOC108349487 Neighboring gene DNA polymerase lambda

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • MGC105884

    Gene Ontology Provided by RGD

    Items 1 - 25 of 27
    Process Evidence Code Pubs
    acts_upstream_of_or_within SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  
    acts_upstream_of_or_within branching involved in mammary gland duct morphogenesis  
    acts_upstream_of_or_within cellular response to organic cyclic compound  
    acts_upstream_of_or_within mammary gland epithelial cell proliferation  
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of T cell receptor signaling pathway  
    involved_in non-canonical NF-kappaB signal transduction  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of circadian rhythm  
    involved_in positive regulation of proteolysis  
    involved_in positive regulation of ubiquitin protein ligase activity  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process  
    acts_upstream_of_or_within protein K48-linked ubiquitination  
    involved_in protein K48-linked ubiquitination  
    acts_upstream_of_or_within protein catabolic process  
    involved_in protein dephosphorylation  
    involved_in protein destabilization  
    involved_in protein polyubiquitination  
    acts_upstream_of_or_within protein ubiquitination  
    involved_in protein ubiquitination  
    acts_upstream_of_or_within regulation of canonical NF-kappaB signal transduction  
    involved_in regulation of canonical Wnt signaling pathway  
    acts_upstream_of_or_within regulation of cell cycle  
    involved_in regulation of circadian rhythm  
    acts_upstream_of_or_within regulation of proteasomal protein catabolic process  
    involved_in ubiquitin-dependent protein catabolic process  
    Items 1 - 25 of 27
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex  
    located_in cytoplasm  
    located_in nucleus  

    General protein information

    Preferred Names
    F-box/WD repeat-containing protein 1A
    Names
    beta-transducin repeat containing protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007148.2NP_001007149.2  F-box/WD repeat-containing protein 1A

      Status: VALIDATED

      Source sequence(s)
      BC085125, CB584165, EV771066
      UniProtKB/TrEMBL
      A0A8I5ZMD6, A0A8I6G2R1
      Conserved Domains (5) summary
      COG2319
      Location:304602
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:317595
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam12125
      Location:153191
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:195242
      F-box-like; F-box-like
      sd00039
      Location:320355
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      254159085..254324819
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006231530.5XP_006231592.1  F-box/WD repeat-containing protein 1A isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZMD6, F1LMH8
      Related
      ENSRNOP00000082092.2, ENSRNOT00000105576.2
      Conserved Domains (5) summary
      COG2319
      Location:290588
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:303581
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam12125
      Location:139177
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:181228
      F-box-like; F-box-like
      sd00039
      Location:306341
      7WD40; WD40 repeat [structural motif]
    2. XM_006231538.5XP_006231600.1  F-box/WD repeat-containing protein 1A isoform X7

      See identical proteins and their annotated locations for XP_006231600.1

      UniProtKB/TrEMBL
      A0A8I5ZMD6, A0A8I6GHM9, A6JHI3
      Related
      ENSRNOP00000093279.2, ENSRNOT00000105391.2
      Conserved Domains (5) summary
      COG2319
      Location:254552
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:267545
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam12125
      Location:103141
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:145192
      F-box-like; F-box-like
      sd00039
      Location:270305
      7WD40; WD40 repeat [structural motif]
    3. XM_006231536.5XP_006231598.1  F-box/WD repeat-containing protein 1A isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZMD6, A0A8I6AFI6
      Related
      ENSRNOP00000091578.2, ENSRNOT00000105194.2
      Conserved Domains (5) summary
      COG2319
      Location:268566
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:281559
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam12125
      Location:117155
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:159206
      F-box-like; F-box-like
      sd00039
      Location:284319
      7WD40; WD40 repeat [structural motif]
    4. XM_006231531.5XP_006231593.1  F-box/WD repeat-containing protein 1A isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZMD6, A0A8I5ZRU0
      Conserved Domains (5) summary
      COG2319
      Location:278576
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:291569
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam12125
      Location:127165
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:169216
      F-box-like; F-box-like
      sd00039
      Location:294329
      7WD40; WD40 repeat [structural motif]
    5. XM_039084629.2XP_038940557.1  F-box/WD repeat-containing protein 1A isoform X9

      UniProtKB/TrEMBL
      A0A8I5ZMD6
      Related
      ENSRNOP00000083705.2, ENSRNOT00000117570.2
      Conserved Domains (4) summary
      cd00200
      Location:255533
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:258293
      7WD40; WD40 repeat [structural motif]
      pfam12125
      Location:91129
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:133180
      F-box-like
    6. XM_039084604.2XP_038940532.1  F-box/WD repeat-containing protein 1A isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZMD6
      Related
      ENSRNOP00000081511.2, ENSRNOT00000105215.2
      Conserved Domains (4) summary
      cd00200
      Location:277555
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:280315
      7WD40; WD40 repeat [structural motif]
      pfam12125
      Location:113151
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:155202
      F-box-like
    7. XM_039084634.2XP_038940562.1  F-box/WD repeat-containing protein 1A isoform X10

      UniProtKB/TrEMBL
      A0A8I5ZMD6
      Related
      ENSRNOP00000089782.2, ENSRNOT00000093843.2
      Conserved Domains (4) summary
      cd00200
      Location:241519
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:244279
      7WD40; WD40 repeat [structural motif]
      pfam12125
      Location:77115
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:119166
      F-box-like
    8. XM_039084642.2XP_038940570.1  F-box/WD repeat-containing protein 1A isoform X11

      UniProtKB/TrEMBL
      A0A8I5ZWB9, Q5U4E5
      Conserved Domains (4) summary
      cd00200
      Location:204482
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:207242
      7WD40; WD40 repeat [structural motif]
      pfam12125
      Location:4078
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:82129
      F-box-like
    9. XM_063268695.1XP_063124765.1  F-box/WD repeat-containing protein 1A isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZMD6, A0A8I5ZX54
      Related
      ENSRNOP00000078424.2, ENSRNOT00000118041.2
    10. XM_063268700.1XP_063124770.1  F-box/WD repeat-containing protein 1A isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZMD6, A0A8I5ZX54
    11. XM_063268728.1XP_063124798.1  F-box/WD repeat-containing protein 1A isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZMD6
    12. XM_063268703.1XP_063124773.1  F-box/WD repeat-containing protein 1A isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZMD6, A0A8I5ZX54
    13. XM_063268710.1XP_063124780.1  F-box/WD repeat-containing protein 1A isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZMD6, A0A8I5ZX54
    14. XM_063268731.1XP_063124801.1  F-box/WD repeat-containing protein 1A isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZMD6
    15. XM_039084638.2XP_038940566.1  F-box/WD repeat-containing protein 1A isoform X11

      UniProtKB/TrEMBL
      A0A8I5ZWB9, Q5U4E5
      Conserved Domains (4) summary
      cd00200
      Location:204482
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:207242
      7WD40; WD40 repeat [structural motif]
      pfam12125
      Location:4078
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:82129
      F-box-like
    16. XM_039084594.2XP_038940522.1  F-box/WD repeat-containing protein 1A isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZMD6, A0A8I5ZX54
      Conserved Domains (4) summary
      cd00200
      Location:285563
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:288323
      7WD40; WD40 repeat [structural motif]
      pfam12125
      Location:121159
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:163210
      F-box-like
    17. XM_063268730.1XP_063124800.1  F-box/WD repeat-containing protein 1A isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZMD6
    18. XM_063268715.1XP_063124785.1  F-box/WD repeat-containing protein 1A isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZMD6, A0A8I6ASK3
    19. XM_017589455.3XP_017444944.1  F-box/WD repeat-containing protein 1A isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZMD6, A0A8I5ZX54
      Related
      ENSRNOP00000022426.7, ENSRNOT00000022426.9
      Conserved Domains (4) summary
      cd00200
      Location:285563
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:288323
      7WD40; WD40 repeat [structural motif]
      pfam12125
      Location:121159
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:163210
      F-box-like
    20. XM_039084622.2XP_038940550.1  F-box/WD repeat-containing protein 1A isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZMD6
      Conserved Domains (4) summary
      cd00200
      Location:259537
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:262297
      7WD40; WD40 repeat [structural motif]
      pfam12125
      Location:95133
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:137184
      F-box-like
    21. XM_006231539.5XP_006231601.1  F-box/WD repeat-containing protein 1A isoform X11

      See identical proteins and their annotated locations for XP_006231601.1

      UniProtKB/TrEMBL
      A0A8I5ZWB9, Q5U4E5
      Conserved Domains (4) summary
      cd00200
      Location:204482
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:207242
      7WD40; WD40 repeat [structural motif]
      pfam12125
      Location:4078
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:82129
      F-box-like
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