Pxmp2 peroxisomal membrane protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pxmp2provided by RGD
Official Full Name: peroxisomal membrane protein 2provided by RGD
Primary source: RGD:61812
See related: EnsemblRapid:ENSRNOG00000037446 AllianceGenome:RGD:61812
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: T44; PMP 22
Summary: Located in peroxisomal membrane. Orthologous to human PXMP2 (peroxisomal membrane protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 1239.8), Heart (RPKM 306.0) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q16

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (52053951..52064283)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (46394051..46404561)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (52452354..52462655)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexcpression and puification of Pxmp2 in Pichia are reported.
Title: Overexpression and purification of rat peroxisomal membrane protein 22, PMP22, in Pichia pastoris.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in peroxisomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisomal membrane	IEA Inferred from Electronic Annotation more info
located_in peroxisomal membrane	ISO Inferred from Sequence Orthology more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: peroxisomal membrane protein 2

Names: 22 kDa peroxisomal membrane protein; liver regeneration-related protein LRRG01; peroxisomal membrane protein 2, 22 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031587.2 → NP_113775.2 peroxisomal membrane protein 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/Swiss-Prot

Q07066

UniProtKB/TrEMBL

A6J2B7, G3V9N2

Related

ENSRNOP00000053518.3, ENSRNOT00000056680.5

Conserved Domains (1) summary

pfam04117
Location:129 → 190

Mpv17_PMP22; Mpv17 / PMP22 family